Usumacinta River in the context of "Chixoy River"

The international border between Guatemala and Mexico measures 871 km (541 mi). It runs between north and west Guatemala (the Guatemalan departments of San Marcos, Huehuetenango, El Quiché and El Petén) and the Mexican states of Campeche, Tabasco and Chiapas. The border includes stretches of the Usumacinta River, the Salinas River, and the Suchiate River.

Geopolitically, this border represents much of the western and northern boundary of the region of Central America within North America. It is across this border that most of the commerce between Mexico and Guatemala and the rest of Central America takes place.

Palenque (Spanish pronunciation: [pa'leŋke]; Yucatec Maya: Bàakʼ [ɓaːkʼ]), also anciently known in the Itza Language as Lakamha ("big water" or "big waters"), was a Maya city-state in southern Mexico that perished in the 8th century. The Palenque ruins date from ca. 226 BC to ca. 799 AD. After its decline, it was overgrown by the jungle of cedar, mahogany, and sapodilla trees, but has since been excavated and restored. It is located near the Usumacinta River in the Mexican state of Chiapas, about 130 km (81 mi) south of Ciudad del Carmen, 150 meters (490 ft) above sea level. It is adjacent to the modern town of Palenque, Chiapas. It averages a humid 26 °C (79 °F) with roughly 2,160 millimeters (85 in) of rain a year.

Palenque is a medium-sized site, smaller than Tikal, Chichen Itza, or Copán, but it contains some of the finest architecture, sculpture, roof comb and bas-relief carvings that the Mayas produced. Much of the history of Palenque has been reconstructed from reading the hieroglyphic inscriptions on the many monuments; historians now have a long sequence of the ruling dynasty of Palenque in the 5th century and extensive knowledge of the city-state's rivalry with other states such as Calakmul and Toniná. The most famous ruler of Palenque was Kʼinich Janaabʼ Pakal, or Pacal the Great, whose tomb has been found and excavated in the Temple of the Inscriptions. By 2005, the discovered area covered up to 2.5 km (0.97 sq mi), but it is estimated that less than 10% of the total area of the city is explored, leaving more than a thousand structures still covered by jungle. Palenque received 920,470 visitors in 2017.

The Lacandon are one of the Maya peoples who live in the jungles of the Mexican state of Chiapas, near the southern border with Guatemala. Their homeland, the Lacandon Jungle, lies along the Mexican side of the Usumacinta River and its tributaries. The Lacandon are one of the most isolated and culturally conservative of Mexico's native peoples. Almost extinct in 1943, today their population has grown significantly, yet remains small, at approximately 650 speakers of the Lacandon language.