University of North Carolina System in the context of University system

Greenville (/ˈɡriːnvɪl/ GREEN-vil; locally /ˈɡriːnvəl/ GREEN-vəl) is the county seat of and the most populous city in Pitt County, North Carolina, United States. As of the 2020 census, the population was 87,521. Greenville’s estimated 2025 population is 96,184. It is the principal city of the Greenville, NC Metropolitan Statistical Area, and the 12th-most populous city in North Carolina. Greenville is the health, entertainment, and educational hub of North Carolina's Tidewater and Coastal Plain. The city has been experiencing an economic and population boom since the 1990s.

Many major companies have moved their regional, national, and international headquarters to Greenville. Companies include Grady-White Boats, Hyster-Yale Materials Handling, Thermo Fisher Scientific, Catalent, and Avient, among others. Greenville is the home of East Carolina University, the fourth-largest university in the University of North Carolina System, and ECU Health Medical Center, the second largest hospital in North Carolina and the flagship hospital for ECU Health and the teaching hospital for the Brody School of Medicine.