Treaty of Apamea in the context of "Roman–Seleucid War"

Classical Anatolia is Anatolia during classical antiquity. Early in that period, Anatolia was divided into several Iron Age kingdoms, most notably Lydia in the west, Phrygia in the center and Urartu in the east. Anatolia fell under Achaemenid Persian rule c. 550 BC. In the aftermath of the Greco-Persian Wars, all of Anatolia remained under Persian control except for the Aegean coast, which was incorporated in the Delian League in the 470s BC. Alexander the Great finally wrested control of the whole region from Persia in the 330s BC. After Alexander's death, his conquests were split amongst several of his trusted generals, but were under constant threat of invasion from both the Gauls and other powerful rulers in Pergamon, Pontus, and Egypt.

The Seleucid Empire, the largest of Alexander's territories, and which included Anatolia, became involved in a disastrous war with Rome culminating in the battles of Thermopylae and Magnesia. The resulting Treaty of Apamea in (188 BC) saw the Seleucids retreat from Anatolia. The Kingdom of Pergamum and the Republic of Rhodes, Rome's allies in the war, were granted the former Seleucid lands in Anatolia. Anatolia subsequently became contested between the neighboring rivalling Romans and the Parthian Empire, which frequently culminated in the Roman–Parthian Wars.

The Battle of Magnesia took place in either December 190 or January 189 BC. It was fought as part of the Roman–Seleucid War, pitting forces of the Roman Republic led by the consul Lucius Cornelius Scipio Asiaticus and the allied Kingdom of Pergamon under Eumenes II against a Seleucid army of Antiochus III the Great. The two armies initially camped northeast of Magnesia ad Sipylum in Asia Minor (modern-day Manisa, Turkey), attempting to provoke each other into a battle on favorable terrain for several days.

When the battle finally began, Eumenes managed to throw the Seleucid left flank into disarray. While Antiochus' cavalry overpowered his adversaries on the right flank of the battlefield, his army's center collapsed before he could reinforce it. Modern estimates give 10,000 dead for the Seleucids and 5,000 killed for the Romans. The battle resulted in a decisive Roman-Pergamene victory, which led to the Treaty of Apamea that ended Seleucid domination in Asia Minor.

Peraia, and Peraea or Peræa (from Ancient Greek: ἡ περαία, hē peraia, "land across") in Classical Antiquity referred to "a community's territory lying 'opposite', predominantly (but not exclusively) a mainland possession of an island state" according to Karl-Wilhelm Welwei. Notable examples include:

• the peraia of Mytilene, which already in the 8th and 7th centuries BC comprised a number of coastal towns from the mouth of the Hellespont to the southern end of the Bay of Adramyttium. It lost this territory to Athens after its failed rebellion in 427 BC against Athenian domination, but appears to have re-acquired a peraia by the mid-4th century BC.
• the Rhodian Peraia, the possessions of Rhodes in southwestern Asia Minor between the 5th century BC and the 1st century BC. Originally comprising parts of coastal Caria, after the Treaty of Apamea this briefly expanded to cover most of Caria and Lycia.
• the peraia of Samos, which established control in ca. 700 BC over the opposite Asian coast from Marathesium to Trogilium and the town of Thebes at Mycale. Possession of the settlements of Carium and Dryussa on Mycale was disputed with Priene until the 2nd century BC, when it was settled through the arbitration of Rhodes.
• the peraia of Samothrace, established by the 5th century BC and stretching from Mesembria to the mouth of the Evros River on the coast of Thrace. It partly survived into the Roman period.
• the peraia of Tenedos, originally south of Sigeum. It survived into the Roman period, but was very limited.
• the peraia of Thasos, established on the coast of Thrace in the 8th century BC and expanded until it comprised the coast between the Strymon and Nestos rivers, as well as the colony of Stryme. It lost control following its failed uprising against Athenian hegemony in 464 BC, but recovered it after the defeat of Athens in the Peloponnesian War and retained it until the late 4th century BC, when the Macedonians took it over. In the 1st century BC, however, the Romans returned it to Thasos.
• the city of Myus was disputed as a peraia between Miletus and Magnesia on the Maeander.
• the Perachora peninsula in Greece, which took its name from its location across from Corinth.
• Perateia was used as a generic term for the post-1204 Crimean possessions of the Empire of Trebizond, including both Greek communities of the area, that is the Khersonites on the southwestern tip of the peninsula (A Protáton republic until its 1299 destruction by a Mongol onslaught), and the Bosporians east of Sudak.
• Perea, also spelled Peraea/Peræa, part of the Herodian Kingdom, now in modern Jordan.