Testes in the context of Sperm

Urology (from Greek οὖρον ouron "urine" and -λογία -logia "study of"), also known as genitourinary surgery, is the branch of medicine that focuses on surgical and medical diseases of the urinary system and the male reproductive organs. Organs under the domain of urology include the kidneys, adrenal glands, ureters, urinary bladder, urethra, and the male reproductive organs (testes, epididymides, vasa deferentia, seminal vesicles, prostate, and penis).

The urinary and reproductive tracts are closely linked, and disorders of one often affect the other. Thus a major spectrum of the conditions managed in urology exists under the domain of genitourinary disorders. Urology combines the management of medical (i.e., non-surgical) conditions, such as urinary-tract infections and benign prostatic hyperplasia, with the management of surgical conditions such as bladder or prostate cancer, kidney stones, congenital abnormalities, traumatic injury, and stress incontinence.

In human anatomy, the penis (/ˈpiːnɪs/; pl.: penises or penes; from the Latin pēnis, initially 'tail') is an external sex organ (intromittent organ) through which males ejaculate and urinate. Together with the testes and surrounding structures, the penis functions as part of the male reproductive system.

The main parts of the penis are the root, body, the epithelium, including the shaft skin, and the foreskin covering the glans. The body of the penis is made up of three columns of tissue: two corpora cavernosa on the dorsal side and corpus spongiosum between them on the ventral side. The urethra passes through the prostate gland, where it is joined by the ejaculatory ducts, and then through the penis. The urethra goes across the corpus spongiosum and ends at the tip of the glans as the opening, called the urinary meatus.

An androgen (from Greek andr-, the stem of the word meaning 'man') is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This includes the embryological development of the primary male sex organs, and the development of male secondary sex characteristics at puberty. Androgens are synthesized in the testes, the ovaries, and the adrenal glands.

Androgens increase in both males and females during puberty. The major androgen in males is testosterone. Dihydrotestosterone (DHT) and androstenedione are of equal importance in male development. DHT in utero causes differentiation of the penis, scrotum and prostate. In adulthood, DHT contributes to balding, prostate growth, and sebaceous gland activity.

Spermatogenesis is the process by which haploid spermatozoa develop from germ cells in the seminiferous tubules of the testicle. This process starts with the mitotic division of the stem cells located close to the basement membrane of the tubules. These cells are called spermatogonial stem cells. The mitotic division of these produces two types of cells. Type A cells replenish the stem cells, and type B cells differentiate into primary spermatocytes. The primary spermatocyte divides meiotically (Meiosis I) into two secondary spermatocytes; each secondary spermatocyte divides into two equal haploid spermatids by Meiosis II. The spermatids are transformed into spermatozoa (sperm) by the process of spermiogenesis. These develop into mature spermatozoa, also known as sperm cells. Thus, the primary spermatocyte gives rise to two cells, the secondary spermatocytes, and the two secondary spermatocytes by their subdivision produce four spermatozoa and four haploid cells.

Spermatozoa are the mature male gametes in many sexually reproducing organisms. Thus, spermatogenesis is the male version of gametogenesis, of which the female equivalent is oogenesis. In mammals it occurs in the seminiferous tubules of the male testes in a stepwise fashion. Spermatogenesis is highly dependent upon optimal conditions for the process to occur correctly, and is essential for sexual reproduction. DNA methylation and histone modification have been implicated in the regulation of this process. It starts during puberty and usually continues uninterrupted until death, although a slight decrease can be discerned in the quantity of produced sperm with increase in age (see Male infertility).

Seasonal breeders are animal species that successfully mate only during certain times of the year. These times of year allow for the optimization of survival of young due to factors such as ambient temperature, food and water availability, and changes in the predation behaviors of other species. Related sexual interest and behaviors are expressed and accepted only during this period. Female seasonal breeders will have one or more estrus cycles only when she is "in season" or fertile and receptive to mating. At other times of the year, they will be anestrus, or have a dearth of their sexual cycle. Unlike reproductive cyclicity, seasonality is described in both males and females. Male seasonal breeders may exhibit changes in testosterone levels, testes weight, and fertility depending on the time of year.

Seasonal breeders are distinct from opportunistic breeders, that mate whenever the conditions of their environment become favorable, and continuous breeders that mate year-round.

Dismemberment is the act of completely disconnecting and removing the limbs, skin or organs from a living or dead being. It has been practiced upon human beings as a form of capital punishment, especially in connection with regicide, but can occur as a result of a traumatic accident, or in connection with murder, suicide, or cannibalism. As opposed to surgical amputation of limbs, dismemberment is often fatal. In criminology, a distinction is made between offensive dismemberment, in which dismemberment is the primary objective of the dismemberer, and defensive dismemberment, in which the motivation is to destroy evidence.

In 2019, American psychiatrists and medical professionals Michael H. Stone, Gary Brucato, and Ann Burgess proposed formal criteria by which "dismemberment" might be systematically distinguished from the act of mutilation, as these terms are commonly used interchangeably. They suggested that dismemberment involves "the entire removal, by any means, of a large section of the body of a living or dead person, specifically, the head (also termed decapitation), arms, hands, torso, pelvic area, legs, or feet". Mutilation, by contrast, involves "the removal or irreparable disfigurement, by any means, of some smaller portion of one of those larger sections of a living or dead person. The latter would include castration (removal of the testes), disembowelment (removal of internal organs), and flaying (removal of the skin)." According to these parameters, removing a whole hand would constitute dismemberment, while removing or damaging a finger would be mutilation; decapitation of a full head would be dismemberment, while removing or damaging a part of the face would be mutilation; and removing a whole torso would be dismemberment, while removing or damaging a breast or the organs contained within the torso would be mutilation.

Gametogonium (plural gametogonia) are stem cells for gametes located within the gonads. They originate from primordial germ cells, which have migrated to the gonads. Male gametogonia which are located within the testes during development and adulthood are called spermatogonium (plural spermatogonia). Female gametogonia, known as oogonium (plural oogonia), are found within the ovaries of the developing foetus and were thought to be depleted at or after birth. Spermatogonia and oogonia are classified as sexually differentiated germ cells.

Sertoli cells are a type of sustentacular "nurse" cell found in human testes which contribute to the process of spermatogenesis (the production of sperm) as a structural component of the seminiferous tubules. They are activated by follicle-stimulating hormone (FSH) secreted by the adenohypophysis and express FSH receptor on their membranes.

Leydig cells, also known as interstitial cells of the testes and interstitial cells of Leydig, are found adjacent to the seminiferous tubules in the testicle and produce testosterone in the presence of luteinizing hormone (LH). They are polyhedral in shape and have a large, prominent nucleus, an eosinophilic cytoplasm, and numerous lipid-filled vesicles. Males have two types of Leydig cells that appear in two distinct stages of development: the fetal type and the adult type.