The Territorial Enterprise, founded by William Jernegan and Alfred James on 18 December 1858, was a newspaper published in Virginia City, Nevada. Published for its first two years in Genoa in what was then Utah Territory, new owners Jonathan Williams and J. B. Woolard moved the paper to Carson City, the capital of the territory, in 1859. The paper changed hands again the next year; Joseph T. Goodman and Denis E. McCarthy moved it again, this time to Virginia City, in 1860.
Noted author Mark Twain wrote for the paper during the 1860s along with writer Dan DeQuille. To cover for DeQuille, who took time off to visit his family in Iowa, the young Sam Clemens was hired. Located steps from the Enterprise offices, Mark Twain and Dan DeQuille, lifelong friends, shared a room at 25 North B St. in Virginia City.
