Tepelenë in the context of Tepelenë District

Laberia (Albanian: Labëria) is a historic region that is roughly situated in southwestern Albania. Its inhabitants are known as Labs (referred to as Albanian: Lab, pl. Lebër, also dial. sing. Lap) and its boundaries reach from Vlorë to Himara in the south, to the Greek border near Sarandë, incorporating the Kurvelesh region of Gjirokastër District and extending east to the city of Tepelenë.

The Drino or Drinos (Albanian: Drino, Greek: Δρίνος) is a river in southern Albania and northwestern Greece, and a tributary of the Vjosë. Its source is in the northwestern part of the Ioannina regional unit, near the village Delvinaki. The 84.6 km (52.6 mi) long Drino flows initially southwest, then northwest and crosses the Albanian border near Ktismata. It continues northwest through Gjirokastër and flows into the Vjosë near Tepelenë.

Mali i Trebeshinës is a massif situated on the border between Përmet and Tepelenë municipalities, in southern Albania.

Part of the Trebeshinë-Dhëmbel-Nemërçkë mountain range, it stretches approximately 15–16 km (9.3–9.9 mi) in length, from the Kiçoku Pass to the Gorge of Këlcyrë, in a northwest-southeast orientation, reaching a height of 1,922 m (6,306 ft).

Shëndelli (lit. 'Holy Sun') is a mountain located in the municipality of Tepelenë, in southern Albania. Situated at the emergence of the Shëndelli-Lunxhëri-Bureto mountain range, its highest elevation is 1,802 m (5,912 ft).

Kurvelesh is a former municipality in the Gjirokastër County, southern Albania. At the 2015 local government reform it became a subdivision of the municipality Tepelenë. The population at the 2011 census was 705. The municipal unit consists of the villages Progonat, Lekdush, Gusmar, Nivicë and Rexhin.

The Battle of the Aous was fought in 198 BC between the Roman Republic and the Kingdom of Macedon, in the area between modern Tepelenë and Këlcyrë in Albania. The Roman forces were led by Titus Quinctius Flamininus and the Macedonian ones were led by Philip V.

The Macedonian army encamped behind a pass in an unassailable position. A local shepherd guided the Romans to a secret path that took them behind the Macedonian position. Flaminius led his troops through this secret path and attacked the Macedonians from the rear, rendering their position untenable and inflicting some 2,000 casualties. Philip's army retreated with the survivors, and the two commanders would meet again at Cynoscephalae the following year, where the Romans would triumph again and end the war.