Ohrid-Prespa Transboundary Biosphere Reserve (Macedonian: Прекуграничен биосферен резерват „Охрид-Преспа“, romanized: Prekugraničen biosferen rezervat „Ohrid-Prespa“; Albanian: Oher – Prespe, Rezerve Ndërkufitare Biosfere) is a biosphere reserve encompassing the area of Lake Ohrid and Lake Prespa, on North Macedonia and Albania.
The reserve was declared in June 2014 and comprises a combination of water bodies and surrounding mountain reliefs, covering an area of 446,244.52 hectares (1,722.96 sq mi).