St. Mary's City, Maryland in the context of "St. Mary's College of Maryland"

The Province of Maryland was an English and later British colony in North America from 1634 until 1776, when the province was one of the Thirteen Colonies that joined in supporting the American Revolution against Great Britain. In 1781, Maryland was the 13th signatory to the Articles of Confederation. The province's first settlement and capital was in St. Mary's City, located at the southern end of St. Mary's County, a peninsula in the Chesapeake Bay bordered by four tidal rivers.

The province began in 1632 as the Maryland Palatinate, a proprietary palatinate granted to Cecil Calvert, 2nd Baron Baltimore, whose father, George, had long sought to found a colony in the New World to serve as a refuge for Catholics at the time of the European wars of religion. Palatines from the Holy Roman Empire also immigrated to Maryland, with many settling in Fredrick County, with Maryland Palatines (Palatine German: Marylandisch Pälzer) reaching a population of 50,000 by 1774.

The Maryland Toleration Act, also known as the Act Concerning Religion, was the first law in North America requiring religious tolerance for Christians. It was passed on April 21, 1649, by the assembly of the Colony of Maryland, in St. Mary's City in St. Mary's County, Maryland. It created one of the pioneer statutes passed by the legislative body of an organized colonial government to guarantee any degree of religious liberty. Specifically, the bill, now usually referred to as the Toleration Act, granted freedom of conscience to all Christians. (The colony which became Rhode Island passed a series of laws, the first in 1636, which prohibited religious persecution including against non-Trinitarians; Rhode Island was also the first government to separate church and state.) Historians argue that it helped inspire later legal protections for freedom of religion in the United States. The Calvert family, who founded Maryland partly as a refuge for English Catholics, sought enactment of the law to protect Catholic settlers and those of other religions that did not conform to the dominant Anglicanism of Britain and her colonies.

The Act allowed freedom of worship for all Trinitarian Christians in Maryland, but sentenced to death anyone who denied the divinity of Jesus. It was revoked in 1654 by William Claiborne, a Virginian who had been appointed as a commissioner by Oliver Cromwell; he was an Anglican, a Puritan sympathizer, and strongly hostile to the Catholic Religion. When the Calverts regained control of Maryland, the Act was reinstated, before being repealed permanently in 1692 following the events of the Glorious Revolution, and the Protestant Revolution in Maryland. As the first law on religious tolerance in British North America, it influenced related laws in other colonies and portions of it were echoed in the writing of the First Amendment to the United States Constitution, which enshrined religious freedom in American law.

Slavery in Maryland lasted over 200 years, from its beginnings in 1642 when the first Africans were brought as slaves to St. Mary's City, to its end after the Civil War. While Maryland developed similarly to neighboring Virginia, slavery declined in Maryland as an institution earlier, and it had the largest free black population by 1860 of any state. The early settlements and population centers of the province tended to cluster around the rivers and other waterways that empty into the Chesapeake Bay. Maryland planters cultivated tobacco as the chief commodity crop, as the market for cash crops was strong in Europe. Tobacco was labor-intensive in both cultivation and processing, and planters struggled to manage workers as tobacco prices declined in the late 17th century, even as farms became larger and more efficient. At first, indentured servants from England supplied much of the necessary labor but, as England's economy improved, fewer came to the colonies. Maryland colonists turned to importing indentured and enslaved Africans to satisfy the labor demand.

By the 18th century, Maryland had developed into a plantation colony and slave society, requiring extensive numbers of field hands for the labor-intensive commodity crop of tobacco. In 1700, the province had a population of about 25,000, and by 1750 that number had grown more than five times to 130,000. By 1755, about 40 percent of Maryland's population was black enslaved people, with African Americans slaves concentrated in the Tidewater counties where tobacco was grown. Planters relied on the extensive system of rivers to transport their produce from inland plantations to the Atlantic coast for export. Baltimore was the second-most important port in the eighteenth-century South, after Charleston, South Carolina.