Sophene in the context of "Armenian highlands"

The Armenian highlands (Armenian: Հայկական լեռնաշխարհ, romanized: Haykakan leṙnašxarh; also known as the Eastern Anatolian highlands, Armenian upland, Armenian plateau, or Armenian tableland) comprise the most central and the highest of the three plateaus that together form the northern sector of West Asia. Clockwise starting from the west, the Armenian highlands are bounded by the Anatolian plateau, the Caucasus, the Kura-Aras lowlands, the Iranian Plateau, and Mesopotamia. The highlands are divided into western and eastern regions, defined by the Ararat Valley where Mount Ararat is located. Since the turn of the 20th century, Western Armenia has been relabeled as "Eastern Anatolia" by Ottoman and Turkish authorities. Eastern Armenia is part of Lesser Caucasus, which was historically known by some as the Anti-Caucasus, meaning "opposite of the Caucasus".

During the Iron Age, the region was known by variations of the name Ararat (Urartu, Uruatri, Urashtu). Later, the Highlands were known as Armenia Major, a central region to the history of Armenians, and one of the four geopolitical regions associated with Armenians, the other three being Armenia Minor, Sophene, and Commagene. The highlands are primarily defined by the geographical dispersal of its native inhabitants, the Armenians. Prior to the appearance of nominally Armenian people in historical records, historians have hypothesized that the region must have been home to various ethnic groups who became homogenous when the Armenian language came to prominence. The population of the Armenian highlands has had a high level of regional genetic continuity for over 6,000 years. Recent studies indicate that the Armenian people descend from the indigenous people of the Armenian highlands and form a distinct genetic isolate in the region. The region was also inhabited during Antiquity by minorities such as Assyrians, Georgians, Greeks, Jews, and Iranians. During the Middle Ages, Arabs and particularly Turkmens and Kurds settled in large numbers in the Armenian highlands.

The Artaxiad dynasty (also Artashesian) ruled the Kingdom of Armenia from 189 BC until their overthrow by the Romans in 12 AD. It was founded by Artaxias I, who claimed kinship with the previous ruling dynasty of Armenia, the Orontids. Their realm included Greater Armenia, Sophene and, intermittently, parts of Mesopotamia. Their main enemies were the Romans, the Seleucids and the Parthians, against whom the Armenians conducted multiple wars. Under the Artaxiad king Tigranes the Great (r. 95–55 BC), the Kingdom of Armenia reached its greatest territorial extent, extending for a brief period from the Caspian to the Mediterranean Sea.