Smallpox vaccine in the context of "Success"

Smallpox was an infectious disease caused by Variola virus (often called Smallpox virus), which belongs to the genus Orthopoxvirus. The last naturally occurring case was diagnosed in October 1977, and the World Health Organization (WHO) certified the global eradication of the disease in 1980, making smallpox the only human disease to have been eradicated to date.

The initial symptoms of the disease included fever and vomiting. This was followed by formation of ulcers in the mouth and a skin rash. Over a number of days, the skin rash turned into the characteristic fluid-filled blisters with a dent in the center. The bumps then scabbed over and fell off, leaving scars. The disease was transmitted from one person to another primarily through prolonged face-to-face contact with an infected person or rarely via contaminated objects. Prevention was achieved mainly through the smallpox vaccine. Once the disease had developed, certain antiviral medications could potentially have helped, but such medications did not become available until after the disease was eradicated. The risk of death was about 30%, with higher rates among babies. Often, those who survived had extensive scarring of their skin, and some were left blind.

Jonathan Edwards (October 5, 1703 – March 22, 1758) was an American revivalist preacher, philosopher, and Congregationalist theologian. Edwards is widely regarded as one of America's most important and original philosophical theologians. Edwards's theological work is broad in scope but rooted in the Puritan heritage as exemplified in the Westminster and Savoy Confessions of Faith. Recent studies have emphasized how thoroughly Edwards grounded his life's work on conceptions of beauty, harmony, and ethical aptness, and how central the Age of Enlightenment was to his mindset. Edwards played a critical role in shaping the First Great Awakening and oversaw some of the first revivals in 1733–35 at his church in Northampton, Massachusetts. His work gave rise to a doctrine known as New England theology.

At a 1741 revival in Enfield, Ct, Edwards delivered the sermon "Sinners in the Hands of an Angry God", a classic of early American literature, following George Whitefield's tour of the Thirteen Colonies. Edwards is well known for his many books, such as The End for Which God Created the World and The Life of David Brainerd, which inspired thousands of missionaries throughout the 19th century, and Religious Affections which many Calvinist Evangelicals still read today. Edwards died from a smallpox inoculation shortly after beginning the presidency at the College of New Jersey in Princeton.

Edward Jenner (17 May 1749 – 26 January 1823) was an English physician and scientist who pioneered the concept of vaccines and created the smallpox vaccine, the world's first vaccine. The terms vaccine and vaccination are derived from Variolae vaccinae ('pustules of the cow'), the term devised by Jenner to denote cowpox. He used it in 1798 in the title of his Inquiry into the Variolae vaccinae known as the Cow Pox, in which he described the protective effect of cowpox against smallpox.

Jenner is often called "the father of immunology", and his work is said to have saved "more lives than any other man". In Jenner's time, smallpox killed around 10% of the global population, with the number as high as 20% in towns and cities where infection spread more easily. In 1821, he was appointed physician to King George IV, and was also made mayor of Berkeley and justice of the peace. He was a member of the Royal Society. In the field of zoology, he was among the first modern scholars to describe the brood parasitism of the cuckoo (Aristotle also noted this behaviour in his History of Animals). In 2002, Jenner was named in the BBC's list of the 100 Greatest Britons.