A skull and crossbones is a symbol consisting of a human skull and two long bones crossed together under or behind the skull. The design originated in the Late Middle Ages as a symbol of death and especially as a memento mori on tombstones. Actual skulls and bones were long used to mark the entrances to Spanish cemeteries (campo santo).
In modern contexts, it is generally used as a hazard symbol, usually in regard to poisonous substances, such as deadly chemicals.