Sinú River in the context of "Magdalena River"

Cartagena (/ˌkɑːrtəˈhɛnə/ KAR-tə-HEN-ə), known since the colonial era as Cartagena de Indias (Spanish: [kaɾtaˈxena ðe ˈindjas] ), is a city and one of the major ports on the northern coast of Colombia in the Caribbean Coast Region, along the Caribbean Sea. Cartagena's past role as a link in the route to the West Indies provides it with important historical value for world exploration and preservation of heritage from the great commercial maritime routes. As a former Spanish colony, it was a key port for the export of Bolivian silver to Spain and for the import of enslaved Africans under the asiento system. It was defensible against pirate attacks in the Caribbean. The city's strategic location between the Magdalena and Sinú rivers also gave it easy access to the interior of New Granada and made it a main port for trade between Spain and its overseas empire, establishing its importance by the early 1540s.

Modern Cartagena is the capital of the Bolívar Department, and had a population of 876,885 according to the 2018 census, making it the second-largest city in the Caribbean region, after Barranquilla, and the fifth-largest city in Colombia. The metropolitan area of Cartagena is the sixth-largest urban area in the country, after metropolitan area of Bucaramanga. Economic activities include the maritime and petrochemical industries, as well as tourism.

The Cordillera Occidental (English: Western Ranges) is the lowest in elevation of the three branches of the Colombian Andes. The average altitude is 2,000 m (6,600 ft) and the highest peak is Cerro Tatamá at 4,100 m (13,500 ft). The range extends from south to north dividing from the Colombian Massif in Nariño Department, passes north through Cauca, Valle del Cauca, Risaralda, Chocó, and Caldas Departments to the Paramillo Massif in Antioquia and Córdoba Departments. The cordillera is paralleled on the east by the Cauca river. From this massif the range divides further to form the Serranías de Ayapel, San Jerónimo and Abibe. Only to recede into the Caribbean plain and the Sinú River valley.

It is a direct continuation of Cordillera Occidental of Ecuador.