In mathematics, sheaf cohomology is the application of homological algebra to analyze the global sections of a sheaf on a topological space. Broadly speaking, sheaf cohomology describes the obstructions (holes) to solving a geometric problem globally when it can be solved locally. The central work for the study of sheaf cohomology is Grothendieck's 1957 Tôhoku paper.
Sheaves, sheaf cohomology, and spectral sequences were introduced by Jean Leray at the prisoner-of-war camp Oflag XVII-A in Austria. From 1940 to 1945, Leray and other prisoners organized a "université en captivité" in the camp.