Seleucids in the context of List of people known as the Great

The Diadochi were the rival generals, families, and friends of Alexander the Great who fought for control over his empire after his death in 323 BC. The Wars of the Diadochi mark the beginning of the Hellenistic period from the Mediterranean Sea to the Indus River Valley.

The most notable Diadochi include Ptolemy, Antigonus, Cassander, and Seleucus as the last remaining at the end of the Wars of the Successors, ruling in Egypt, Asia-Minor, Macedon and Persia respectively, with Ptolemaic, Antigonid and Seleucid dynasties lasting several centuries.

The Artaxiad dynasty (also Artashesian) ruled the Kingdom of Armenia from 189 BC until their overthrow by the Romans in 12 AD. It was founded by Artaxias I, who claimed kinship with the previous ruling dynasty of Armenia, the Orontids. Their realm included Greater Armenia, Sophene and, intermittently, parts of Mesopotamia. Their main enemies were the Romans, the Seleucids and the Parthians, against whom the Armenians conducted multiple wars. Under the Artaxiad king Tigranes the Great (r. 95–55 BC), the Kingdom of Armenia reached its greatest territorial extent, extending for a brief period from the Caspian to the Mediterranean Sea.

Mithridates II (also spelled Mithradates II or Mihrdad II; Parthian: 𐭌𐭄𐭓𐭃𐭕 Mihrdāt) was king of the Parthian Empire from 124 to 91 BC. Considered one of the greatest of his dynasty to ever rule, he was known as Mithridates the Great in antiquity.

Mithridates II was crowned king after the abrupt death of his predecessor Artabanus I. Inheriting a declining empire that was reeling from military pressure in both the east and west, Mithridates II quickly stabilized the situation in Mesopotamia by gaining the allegiance of Characene, and subduing the insurgent Kingdom of Elymais and also the Arabs, who had continuously raided Babylonia. Mithridates II was the first Parthian king to extend Parthian rule into the Caucasus, where the kingdoms of Armenia, Iberia, and possibly Caucasian Albania became Parthian vassal states. To the east, he defeated and conquered the nomadic tribes in Bactria who had killed both of his predecessors. Sakastan was also reconquered, which was given as a fiefdom to the House of Suren. In 114/113 BC, he seized Dura-Europos in Syria from the Seleucids, and by 95 BC, the northern Mesopotamian kingdoms of Adiabene, Gordyene, and Osrhoene had acknowledged his authority. Under Mithridates II, the Parthian Empire reached it's zenith and extended from Syria and the Caucasus to Central Asia and India. It was under Mithridates II that the Parthian Empire for the first time established diplomatic relations with Rome and Han China.

This is a list of people known as the Great, or the equivalent, in their own language. Other languages have their own suffixes, such as Persian e Bozorg and Hindustani e Azam.

In Persia, the title "the Great" at first seems to have been a colloquial version of the Old Persian title "Great King" (King of Kings, Shahanshah). It was first used by Cyrus II of Persia. The title was inherited by Alexander III when he conquered the Persian Empire, and the epithet eventually became personally associated with him. The first reference to this is in a comedy by Plautus, in which it is assumed that everyone knew who "Alexander the Great" was; however, there is no evidence that he was called "the Great" before this. The early Seleucid kings, who succeeded Alexander in Persia, used "Great King" in local documents, but the title was most notably used for Antiochus III. Once the term gained currency, it was broadened to include persons in other fields, such as the philosopher Albert.