The second Johnson ministry began on 16 December 2019, three days after Boris Johnson's audience with Queen Elizabeth II where she invited him to form a new government following the 2019 general election. The Conservative Party was returned to power with a majority of 80 seats in the House of Commons. Initially the ministers were largely identical to those at the end of the first Johnson ministry, but changed significantly in cabinet reshuffles in February 2020 and September 2021.
In July 2022, following a government crisis as a result of dozens of resignations from his government, Johnson announced his resignation as leader of the Conservative Party. Johnson pledged to remain as prime minister and lead a 'caretaker' government until a new Conservative Party leader had been elected. The election results were revealed on Monday 5 September 2022, and the new leader Liz Truss became prime minister on 6 September, resulting in the cabinet's dissolution.