Sebezhsky District (Russian: Се́бежский райо́н) is an administrative and municipal district (raion), one of the twenty-four in Pskov Oblast, Russia. It is located in the southwest of the oblast and borders Rasony and Verkhnyadzvinsk Districts of Vitebsk Oblast, Belarus to the south; Zilupe, Ludza, and Cibla municipalities of Latvia to the west; Krasnogorodsky and Opochetsky Districts to the north; and Pustoshkinsky and Nevelsky Districts to the east. The area of the district is 3,100 square kilometers (1,200 sq mi). Its administrative center is the town of Sebezh.
As of the 2010 Census, the population of Sebezh was 21,674, down from 25,473 in 2002 and 26,926 in 1989. Sebezh accounts for 29.4% of the district's total population.