Schneller Orphanage in the context of Jerusalem University College

The expansion of Jerusalem outside of the Old City walls, which included shifting the city center to the new neighborhoods, started in the mid-19th century and by the early 20th century had entirely transformed the city. Prior to the 19th century, the main built up areas outside the walls were the complex around King David's Tomb on the southern Mount Zion, and the village of Silwan.

In the mid-19th century, with an area of only one square kilometer, the Old City had become overcrowded and unsanitary, with rental prices on a constant rise. In the mid-1850s, following the Crimean War, institutions including the Russian Compound, Kerem Avraham, the Schneller Orphanage, Bishop Gobat school and the Mishkenot Sha'ananim compound, marked the beginning of permanent settlement outside Jerusalem's Old City walls.

Kerem Avraham, in English Abraham's Vineyard, is a neighbourhood near Geula in central Jerusalem, founded in 1855. It is bounded by Malkhei Yisrael Street, Yechezkel Street, Tzefanya Street, and the Schneller Compound.

The 1855 mission house was one of the first structures to be built outside the Old City of Jerusalem; the others are the Schneller Orphanage, the Bishop Gobat school, Mishkenot Sha’ananim, and the Russian Compound.

Mishkenot Sha'ananim (Hebrew: משכנות שאננים, lit. Peaceful Dwellings) was the first Jewish settlement built outside the walls of the Old City of Jerusalem, on a hill directly across Mount Zion. It was built in 1859–1860. This guesthouse was one of the first structures to be built outside the Old City, the others being Kerem Avraham, the Schneller Orphanage, Bishop Gobat school, and the Russian Compound.