Santiago Ramón y Cajal in the context of "Neuroscientific"

Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions, and its disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developmental biology, cytology, psychology, physics, computer science, chemistry, medicine, statistics, and mathematical modeling to understand the fundamental and emergent properties of neurons, glia, and neural circuits. The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the "epic challenge" of the biological sciences.

The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales. The techniques used by neuroscientists have expanded enormously, from molecular and cellular studies of individual neurons to imaging of sensory, motor, and cognitive tasks in the brain.

A neuroscientist (or neurobiologist) is a scientist specializing in neuroscience that deals with the anatomy and function of neurons, neural circuits, and glia, and their behavioral, biological, and psychological roles in health and disease.

Neuroscientists generally work as researchers within a college, university, government agency, or private industry setting. In research-oriented careers, neuroscientists design and conduct scientific experiments on the nervous system and its functions. They can engage in basic or applied research. Basic research seeks to expand current understanding of the nervous system, whereas applied research seeks to address a specific problem, such as developing a treatment for a neurological disorder.

In biology and other experimental sciences, an in silico experiment is one performed on a computer or via computer simulation software. The phrase is pseudo-Latin for 'in silicon' (correct Latin: in silicio), referring to silicon in computer chips. It was coined in 1987 as an allusion to the Latin phrases in vivo, in vitro, and in situ, which are commonly used in biology (especially systems biology). The latter phrases refer, respectively, to experiments done in living organisms, outside living organisms, and where they are found in nature.

Camillo Golgi (Italian: [kaˈmillo ˈɡɔldʒi]; 7 July 1843 – 21 January 1926) was an Italian biologist and pathologist who was awarded the 1906 Nobel Prize in Physiology or Medicine for his works on the central nervous system. He studied medicine at the University of Pavia (where he later spent most of his professional career) between 1860 and 1868 under the tutelage of Cesare Lombroso. Inspired by pathologist Giulio Bizzozero, he pursued research in the nervous system. His discovery of a staining technique called black reaction (sometimes called Golgi's method or Golgi's staining in his honour) in 1873 was a major breakthrough in neuroscience. Several structures and phenomena in anatomy and physiology are named for him, including the Golgi apparatus, the Golgi tendon organ and the Golgi tendon reflex.

Golgi and the Spanish biologist Santiago Ramón y Cajal were jointly awarded the Nobel Prize in Physiology or Medicine in 1906 "in recognition of their work on the structure of the nervous system".

The neuron doctrine is the concept that the nervous system is made up of discrete individual cells, a discovery due to decisive neuro-anatomical work of Santiago Ramón y Cajal and later presented by, among others, H. Waldeyer-Hartz. The term neuron (spelled neurone in British English) was itself coined by Waldeyer as a way of identifying the cells in question. The neuron doctrine, as it became known, served to position neurons as special cases under the broader cell theory evolved some decades earlier. He appropriated the concept not from his own research but from the disparate observation of the histological work of Albert von Kölliker, Camillo Golgi, Franz Nissl, Santiago Ramón y Cajal, Auguste Forel and others.

The name granule cell has been used for a number of different types of neurons whose only common feature is that they all have very small cell bodies. Granule cells are found within the granular layer of the cerebellum, the dentate gyrus of the hippocampus, the superficial layer of the dorsal cochlear nucleus, the olfactory bulb, and the cerebral cortex.

Cerebellar granule cells account for the majority of neurons in the human brain. These granule cells receive excitatory input from mossy fibers originating from pontine nuclei. Cerebellar granule cells project up through the Purkinje layer into the molecular layer where they branch out into parallel fibers that spread through Purkinje cell dendritic arbors. These parallel fibers form thousands of excitatory granule-cell–Purkinje-cell synapses onto the intermediate and distal dendrites of Purkinje cells using glutamate as a neurotransmitter.