Santa Maria delle Grazie, Milan in the context of "Apostles in the New Testament"

The history of Christianity begins with Jesus, an itinerant Jewish preacher and teacher, who was crucified in Jerusalem c. AD 30–33. His followers proclaimed that he was the incarnation of God and had risen from the dead. In the two millennia since, Christianity has spread across the world, becoming the world's largest religion with over two billion adherents worldwide.

Initially, Christianity was a mostly urban grassroots movement. Its religious text was written in the first century. A formal church government developed, and it grew to over a million adherents by the third century. Constantine the Great issued the Edict of Milan legalizing it in 315. Christian art, architecture, and literature blossomed during the fourth century, but competing theological doctrines led to divisions. The Nicene Creed of 325, the Nestorian schism, the Church of the East and Oriental Orthodoxy resulted. While the Western Roman Empire ended in 476, its successor states and its eastern compatriot—the Byzantine Empire—remained Christian.

The Last Supper (Italian: Il Cenacolo [il tʃeˈnaːkolo] or L'Ultima Cena [ˈlultima ˈtʃeːna]) is a mural painting by the Italian High Renaissance artist Leonardo da Vinci, dated to c. 1495–1498, housed in the refectory of the Convent of Santa Maria delle Grazie in Milan, Italy. The painting represents the scene of the Last Supper of Jesus with the Twelve Apostles, as it is told in the Gospel of John – specifically the moment after Jesus announces that one of his apostles will betray him. Its handling of space, mastery of perspective, treatment of motion and complex display of human emotion has made it one of the Western world's most recognizable paintings and among Leonardo's most celebrated works. Some commentators consider it pivotal in inaugurating the transition into what is now termed the High Renaissance.

The work was commissioned as part of a plan of renovations to the church and its convent buildings by Leonardo's patron Ludovico Sforza, Duke of Milan. In order to permit his inconsistent painting schedule and frequent revisions, it is painted with materials that allowed for regular alterations: tempera on gesso, pitch, and mastic. Due to the methods used, a variety of environmental factors, and intentional damage, little of the original painting remains today despite numerous restoration attempts, the last being completed in 1999. The Last Supper is Leonardo's largest work, aside from the Sala delle Asse.

The Last Supper is the final meal that, in the Gospel accounts, Jesus shared with his apostles in Jerusalem before his crucifixion. The Last Supper is commemorated by Christians especially on Holy Thursday. The Last Supper provides the scriptural basis for the Eucharist, also known as "Holy Communion" or "The Lord's Supper". Jesus having a final meal with his disciples is almost beyond dispute among scholars, and belongs to the framework of the narrative of Jesus' life.

The New Testament mentions the Last Supper in four of its books. The First Epistle to the Corinthians (I Cor. 11:23–25) contains the earliest known mention. The four canonical gospels state that the Last Supper took place in the week of Passover, days after Jesus's triumphal entry into Jerusalem, and before Jesus was crucified on Good Friday (Matthew 26:17–29; Mark 14:12–25; Luke 22:7–38). During the meal, Jesus predicts his betrayal by one of the apostles present, and foretells that before the next morning, Peter will thrice deny knowing him.

The Last Supper of Jesus and the Twelve Apostles has been a popular subject in Christian art, often as part of a cycle showing the Life of Christ. Depictions of the Last Supper in Christian art date back to early Christianity and can be seen in the Catacombs of Rome.

The Last Supper was depicted both in the Eastern and Western Churches. By the Renaissance, it was a favorite subject in Italian art. It was also one of the few subjects to be continued in Lutheran altarpieces for a few decades after the Protestant Reformation.