Saint Boniface Hospital (French: Hôpital Saint-Boniface; also called St. B; previously called the Saint-Boniface General Hospital) is Manitoba's second-largest hospital, located in the St. Boniface neighbourhood of Winnipeg. Founded by the Sisters of Charity (Grey Nuns) of Montreal in 1871, it was the first hospital in Western Canada. The hospital was incorporated in 1960, and as of 2023 has 440 beds and 30 bassinets.
St. Boniface Hospital is a tertiary health care facility, employing nearly 3,500 staff and 340 doctors with admitting privileges. The St. Boniface Hospital & Research Foundation is the primary fundraising organization for the hospital. St. Boniface is a regional centre for cardiac care. It also provides diagnostic imaging and hemodialysis for the Winnipeg Regional Health Authority.