Roman Catholic Archdiocese of Mexico in the context of Roman Catholic Diocese of Xochimilco

The Metropolitan Cathedral of the Assumption of the Most Blessed Virgin Mary into Heaven (Spanish: Catedral Metropolitana de la Asunción de la Bienaventurada Virgen María a los cielos), also commonly called the Mexico City Metropolitan Cathedral, is the cathedral church of the Catholic Archdiocese of Mexico. It is situated on top of the former Aztec sacred precinct near the Templo Mayor on the northern side of the Plaza de la Constitución (Zócalo) in the historic center of Mexico City. The cathedral was built in sections from 1573 to 1813 around the original church that was constructed soon after the Spanish conquest of Tenochtitlan, eventually replacing it entirely. Spanish architect Claudio de Arciniega planned the construction, drawing inspiration from Gothic cathedrals in Spain.

Due to the long time it took to build it, just under 250 years, virtually all the main architects, painters, sculptors, gilding masters and other plastic artists of the viceroyalty worked at some point in the construction of the enclosure. The long construction time also led to the integration of a number of architectural styles in its design, including the Gothic, Baroque, Churrigueresque, Neoclassical styles, as they came into vogue over the centuries. It furthermore allowed the cathedral to include different ornaments, paintings, sculptures and furniture in its interior. The project was a point of social cohesion, because it involved so many generations and social classes, including ecclesiastical authorities, government authorities, and different religious orders.

Juan Diego Cuauhtlatoatzin (1474–1548), also known simply as Juan Diego (Spanish pronunciation: [ˌxwanˈdjeɣo]), was a Nahua peasant and Marian visionary. He is said to have been granted apparitions of Our Lady of Guadalupe on four occasions in December 1531: three at the hill of Tepeyac and a fourth before don Juan de Zumárraga, then the first bishop of Mexico. The Basilica of Our Lady of Guadalupe, located at the foot of Tepeyac, houses the cloak (tilmahtli) that is traditionally said to be Juan Diego's, and upon which the image of the Virgin is said to have been miraculously impressed as proof of the authenticity of the apparitions.

Juan Diego's visions and the imparting of the miraculous image, as recounted in oral and written colonial sources such as the Huei tlamahuiçoltica, are together known as the Guadalupe event (Spanish: el acontecimiento Guadalupano), and are the basis of the veneration of Our Lady of Guadalupe. This veneration is ubiquitous in Mexico, prevalent throughout the Spanish-speaking Americas, and increasingly widespread beyond. As a result, the Basilica of Our Lady of Guadalupe is now one of the world's major Christian pilgrimage destinations, receiving 22 million visitors in 2010.

The Basilica of Santa María de Guadalupe, officially called Insigne y Nacional Basílica de Santa María de Guadalupe (in English: Basilica of Our Lady of Guadalupe) is a basilica of the Catholic Church, dedicated to the Virgin Mary in her invocation of Our Lady of Guadalupe, located at the foot of the Hill of Tepeyac in the Gustavo A. Madero borough of Mexico City. It belongs to the Primate Archdiocese of Mexico through the Guadalupana Vicariate, which since November 4, 2018, is in the care of Monsignor Efraín Hernández Díaz, who has the title of general and episcopal vicar of Guadalupe and abbot of the basilica.

Every year some twenty million pilgrims visit the sanctuary, of which about nine million do so in the days around December 12, the day on which Our Lady of Guadalupe is celebrated. Annually, the Basilica of Santa María de Guadalupe has at least twice as many visitors as the best-known Marian shrines.