Research ethics in the context of "Institutional review board"

A hypothesis (pl.: hypotheses) is a proposed explanation for a phenomenon. A scientific hypothesis must be based on observations and make a testable and reproducible prediction about reality, in a process beginning with an educated guess or thought. If a hypothesis is repeatedly independently demonstrated by experiment to be true, it becomes a scientific theory. In colloquial usage, the words "hypothesis" and "theory" are often used interchangeably, but this is incorrect in the context of science.

A working hypothesis is a provisionally-accepted hypothesis used for the purpose of pursuing further progress in research. Working hypotheses are frequently discarded, and often proposed with knowledge (and warning) that they are incomplete and thus false, with the intent of moving research in at least somewhat the right direction, especially when scientists are stuck on an issue and brainstorming ideas.

A thought experiment is an imaginary scenario that is meant to elucidate or test an argument or theory. It is often an experiment that would be hard, impossible, or unethical to actually perform. It can also be an abstract hypothetical that is meant to test our intuitions about morality or other fundamental philosophical questions.

A style guide is a set of standards for the writing, formatting, and design of documents. A book-length style guide is often called a style manual or a manual of style. A short style guide, typically ranging from several to several dozen pages, is often called a style sheet. The standards documented in a style guide are applicable for either general use, or prescribed use in an individual publication, particular organization, or specific field.

A style guide establishes standard style requirements to improve communication by ensuring consistency within and across documents. They may require certain best practices in writing style, usage, language composition, visual composition, orthography, and typography by setting standards of usage in areas such as punctuation, capitalization, citing sources, formatting of numbers and dates, table appearance and other areas. For academic and technical documents, a guide may also enforce best practices in ethics (such as authorship, research ethics, and disclosure) and compliance (technical and regulatory). For translations, a style guide may even be used to enforce consistent grammar, tone, and localization decisions such as units of measure.

Beneficence in general means "active well-doing". Duties of beneficence form a part of various religious and secular ethical theories. As an applied ethical concept relating to research, beneficence means that researchers should have the welfare of the research participant as a goal of any clinical trial or other research study. The antonym of this term, maleficence, describes a practice that opposes the welfare of any research participant. According to the Belmont Report, researchers are required to follow two moral requirements in line with the principle of beneficence: do not harm, and maximize possible benefits for research while minimizing any potential harm on others.

The idea that medical professionals and researchers would always practice beneficence seems natural to most patients and research participants, but in fact, every health intervention or research intervention has potential to harm the recipient. There are many different precedents in medicine and research for conducting a cost–benefit analysis and judging whether a certain action would be a sufficient practice of beneficence, and the extent to which treatments are acceptable or unacceptable is under debate.

The Declaration of Helsinki (DoH, Finnish: Helsingin julistus) is a set of ethical principles regarding human experimentation developed originally in 1964 for the medical community by the World Medical Association (WMA). It is widely regarded as the cornerstone document on human research ethics.

It is not a legally binding instrument under international law, but instead draws its authority from the degree to which it has been codified in, or influenced, national or regional legislation and regulations. Its role was described by a Brazilian forum in 2000 in these words: "Even though the Declaration of Helsinki is the responsibility of the World Medical Association, the document should be considered the property of all humanity."

The Nuremberg Code (German: Nürnberger Kodex) is a set of ethical research principles for human experimentation created by the court in U.S. v Brandt, one of the Subsequent Nuremberg trials that were held after the Second World War.

Though it was articulated as part of the court's verdict in the trial, the Code would later become significant beyond its original context; in a review written on the 50th anniversary of the Brandt verdict, Jay Katz writes that "a careful reading of the judgment suggests that [the authors] wrote the Code for the practice of human experimentation whenever it is being conducted."

Scientific misconduct is the violation of the standard codes of scholarly conduct and ethical behavior in the publication of professional scientific research. It is the violation of scientific integrity: violation of the scientific method and of research ethics in science, including in the design, conduct, and reporting of research.