Relapse in the context of "Multiple sclerosis"

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⭐ Core Definition: Relapse

In internal medicine, relapse or recidivism is a recurrence of a past (typically medical) condition. For example, multiple sclerosis and malaria often exhibit peaks of activity and sometimes very long periods of dormancy, followed by relapse or recrudescence.

In psychiatry, relapse or reinstatement of drug-seeking behavior, is the recurrence of pathological drug use, self harm or other symptoms after a period of recovery. Relapse is often observed in individuals who have developed a drug addiction or a form of drug dependence, as well as those who have a mental disorder.

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Relapse in the context of Recidivism

Recidivism (/rɪˈsɪdɪvɪzəm/; from Latin: recidivus 'recurring', derived from re- 'again' and cadere 'to fall') is the act of a person repeating an undesirable behavior after they have experienced negative consequences of that behavior, or have been trained to extinguish it. Recidivism is also used to refer to the percentage of former prisoners who are rearrested for a similar offense.

The term is frequently used in conjunction with criminal behavior and substance abuse. Recidivism is a synonym of relapse, which is more commonly used in medicine and in the disease model of addiction.

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Relapse in the context of Alcohol use and sleep

Alcohol use and sleep have a complex relationship. While alcohol may initially induce drowsiness, it can disrupt sleep quality and exacerbate sleep disorders in the long run. During abstinence, sleep disruption is one of the greatest predictors of relapse.

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Relapse in the context of Relapsing–remitting

Relapsing–remitting is a medical term referring to a presentation of disease symptoms that become worse over time (relapsing), followed by periods of less severe symptoms that do not completely cease (partial remitting). The term is used to describe a type of multiple sclerosis called relapsing–remitting multiple sclerosis, where unpredictable relapses are followed by remission for months to years.

The term is also used to describe palindromic rheumatism in the context of rheumatoid arthritis, catatonia, lupus, mental disorders, and experimental autoimmune encephalomyelitis.

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Relapse in the context of Psychiatric medication

A psychiatric or psychotropic medication is a psychoactive drug taken to exert an effect on the chemical makeup of the brain and nervous system. Thus, these medications are used to treat mental illnesses. These medications are typically made of synthetic chemical compounds and are usually prescribed in psychiatric settings, potentially involuntarily during commitment. Since the mid-20th century, such medications have been leading treatments for a broad range of mental disorders and have decreased the need for long-term hospitalization, thereby lowering the cost of mental health care. The recidivism or rehospitalization of the mentally ill is at a high rate in many countries, and the reasons for the relapses are under research.

A 2022 umbrella review of over 100 meta-analyses found that both psychotherapies and pharmacotherapies for adult mental disorders generally yield small effect sizes, suggesting current treatment research may have reached a ceiling and needs a paradigm shift.

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Relapse in the context of Physical dependence

Physical dependence is a physical condition caused by chronic use of a tolerance-forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms. Physical dependence can develop from low-dose therapeutic use of certain medications such as benzodiazepines, opioids, stimulants, antiepileptics and antidepressants, as well as the recreational misuse of drugs such as alcohol, opioids and benzodiazepines. The higher the dose used, the greater the duration of use, and the earlier age use began are predictive of worsened physical dependence and thus more severe withdrawal syndromes. Acute withdrawal syndromes can last days, weeks or months. Protracted withdrawal syndrome, also known as post-acute-withdrawal syndrome or "PAWS", is a low-grade continuation of some of the symptoms of acute withdrawal, typically in a remitting-relapsing pattern, often resulting in relapse and prolonged disability of a degree to preclude the possibility of lawful employment. Protracted withdrawal syndrome can last for months, years, or depending on individual factors, indefinitely. Protracted withdrawal syndrome is noted to be most often caused by benzodiazepines as well as opioids. To dispel the popular misassociation with addiction, physical dependence to medications is sometimes compared to dependence on insulin by persons with diabetes.

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Relapse in the context of Remission (medicine)

Remission is either the reduction or disappearance of the signs and symptoms of a disease. The term may also be used to refer to the period during which this reduction occurs. A remission may be considered a partial remission or a complete remission. Each disease, type of disorder, or clinical trial can have its own definition of a partial remission. For example, a partial remission for cancer may be defined as a 50% or greater reduction in the measurable parameters of tumor growth as may be found on physical examination, radiologic study, or by biomarker levels from a blood or urine test.

A complete remission, also called a full remission, is a total disappearance of the signs and symptoms of a disease. A person whose condition is in complete remission may be considered cured or recovered. Relapse is a term to describe returning symptoms of the disease after a period of remission. In cancer-treatment, doctors usually avoid the term "cured" and instead prefer the term "no evidence of disease" (NED) to refer to a complete remission of cancer, which does not rule out the possibility of relapse.

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Relapse in the context of Recrudescence

Recrudescence is the recurrence of an undesirable condition. In medicine, it is usually defined as the recurrence of symptoms after a period of remission or quiescence, in which sense it can sometimes be synonymous with relapse. In a narrower sense, it can also be such a recurrence with higher severity than before the remission. "Relapse" conventionally has a specific (albeit somewhat illogical) meaning when used in relation to malaria (see below).

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Relapse in the context of Mindfulness-based cognitive therapy

Mindfulness-based cognitive therapy (MBCT) is an approach to psychotherapy that uses cognitive behavioral therapy (CBT) methods in conjunction with mindfulness meditative practices and similar psychological strategies. The origins to its conception and creation can be traced back to the traditional approaches from East Asian formative and functional medicine, philosophy and spirituality, birthed from the basic underlying tenets from classical Taoist, Buddhist and Traditional Chinese medical texts, doctrine and teachings.

Recently, mindfulness therapy has become of great interest to the scientific and medical community in the West, leading to the development of many new innovative approaches to preventative and treatment strategies to physical and mental health conditions and care. One such approach is the relapse-prevention for individuals with major depressive disorder (MDD). A focus on MDD and attention to negative thought processes such as false beliefs and rumination, distinguishes MBCT from other mindfulness-based therapies. Mindfulness-based stress reduction (MBSR), for example, is a more generalized program that also utilizes the practice of mindfulness. MBSR is a group-intervention program, like MBCT, that uses mindfulness to help improve the lives of individuals with chronic clinical ailments and high-stress.

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