The Rebellion of Túpac Amaru II (4 November 1780 – 15 March 1783) was an uprising by cacique-led Aymara, Quechua, and mestizo rebels aimed at overthrowing Spanish colonial rule in Peru. The causes of the rebellion included opposition to the Bourbon Reforms, an economic downturn in colonial Peru, and a grassroots revival of Inca cultural identity led by Túpac Amaru II, an indigenous cacique and the leader of the rebellion. While Amaru II was captured and executed by the Spanish in 1781, the rebellion continued for at least another year under other rebel leaders. Amaru II's rebellion was simultaneous, and occasionally cooperated, with the uprising of Túpac Katari in colonial-era Upper Peru (now Bolivia). The rebellion was the first large-scale attempt at an independence movement in Latin America and among the largest rebellions of the 18th century.
The rebellion arose as a reaction to the imposition of the Bourbon Reforms in the Spanish viceroyalties of America and was led by the curaca José Gabriel Condorcanqui, known as Túpac Amaru II. These reforms, among others, forced the indigenous population to mine minerals under the Mit'a system. Among Túpac Amaru II's proclamations were the demands of the freedom of the indigenous population and the abolition of slavery.