Prefrontal cortex in the context of "Brodmann area 9"

The frontal lobe is the largest lobe of the vertebrate brain and the most anterior lobe of the cerebral hemispheres. The anatomical groove known as the central sulcus separates the frontal lobe from the parietal lobe, and the deeper anatomical groove called the lateral sulcus separates the frontal lobe from the temporal lobe. The most anterior ventral, orbital end of the frontal lobe is known as the frontal pole, which is one of the three so-called poles of the cerebrum.

The outer, multifurrowed surface of the frontal lobe is called the frontal cortex. Like all cortical tissue, the frontal cortex is a thin layer of gray matter making up the outer portion of the brain. The frontal cortex is further subdivided into several anatomical and functional structures, including those of the motor cortex (the premotor cortex, the nonprimary motor cortex, the primary motor cortex) and the prefrontal cortex (e.g., the dorsolateral prefrontal cortex).

Inhibitory control, also known as response inhibition, is a cognitive process – and, more specifically, an executive function – that permits an individual to inhibit their impulses and natural, habitual, or dominant behavioral responses to stimuli (a.k.a. prepotent responses) in order to select a more appropriate behavior that is consistent with completing their goals. Self-control is an important aspect of inhibitory control. For example, successfully suppressing the natural behavioral response to eat cake when one is craving it while dieting requires the use of inhibitory control.

The prefrontal cortex, caudate nucleus, and subthalamic nucleus are known to regulate inhibitory control cognition. Inhibitory control is impaired in both addiction and attention deficit hyperactivity disorder. In healthy adults and ADHD individuals, inhibitory control improves over the short term with low (therapeutic) doses of methylphenidate or amphetamine. Inhibitory control may also be improved over the long-term via consistent aerobic exercise.

The dorsolateral prefrontal cortex (DLPFC or DL-PFC) is an area in the prefrontal cortex of the primate brain. It is one of the most recently derived parts of the human brain. It undergoes a prolonged period of maturation which lasts into adulthood. The DLPFC is not an anatomical structure, but rather a functional one. It lies in the middle frontal gyrus of humans (i.e., lateral part of Brodmann's area (BA) 9 and 46). In macaque monkeys, it is around the principal sulcus (i.e., in Brodmann's area 46). Other sources consider that DLPFC is attributed anatomically to BA 9 and 46 and BA 8, 9 and 10.

The DLPFC has connections with the orbitofrontal cortex, as well as the thalamus, parts of the basal ganglia (specifically, the dorsal caudate nucleus), the hippocampus, and primary and secondary association areas of neocortex (including posterior temporal, parietal, and occipital areas). The DLPFC is also the end point for the dorsal pathway (stream), which is concerned with how to interact with stimuli.

The inferior frontal gyrus (IFG; also gyrus frontalis inferior) is the lowest positioned gyrus of the frontal gyri, of the frontal lobe, and is part of the prefrontal cortex.

Its superior border is the inferior frontal sulcus (which divides it from the middle frontal gyrus), its inferior border is the lateral sulcus (which divides it from the superior temporal gyrus) and its posterior border is the inferior precentral sulcus. Above it is the middle frontal gyrus, behind it is the precentral gyrus.

Evolutionary explanations for the existence of discrete emotions such as fear and joy are one of many theoretical approaches to understanding the ontological nature of emotions. Historically, evolutionary theoretical approaches to emotions, including basic emotion theory, have postulated that certain so-called basic emotions (usually fear, joy, anger, disgust, and sadness) have evolved over human phylogeny to serve specific functions (for example, fear alerts a human mind of imminent danger). So-called basic emotions are often linked causally to subcortical structures of the brain, including the amygdala (pronounced uh-MIG-duh-luh). In other words, subcortical structures have historically been considered the causes of emotions, while neocortical (neo- meaning new, recent and cortical meaning relating to cortex) structures, especially the prefrontal cortex, are almost invariably understood as the cause of reason. Those ideas about the brain are old; they're traceable at least to Aristotle and were later incorporated into Paul MacLean's mistaken model of brain organization, the "triune brain." These ideas have led to the widespread, erroneous belief that animal brains, including human brains, evolve in a linear fashion, such that, along the course of evolution, new layers of brain tissue are stacked upon older layers of brain tissue, much like the formation of sedimentary rocks. Brain evolution is a lot more complicated than that.

Evolution and natural selection has been applied to the study of human communication, mainly by Charles Darwin in his 1872 work, The Expression of the Emotions in Man and Animals. Darwin researched the expression of emotions in an effort to support his materialist theory of unguided evolution. He proposed that much like other traits found in animals, emotions apparently also evolved and were adapted over time. His work looked at not only facial expressions in animals and specifically humans, but attempted to point out parallels between behaviors in humans and other animals.

The orbitofrontal cortex (OFC) is a prefrontal cortex region in the frontal lobes of the brain which is involved in the cognitive process of decision-making. In non-human primates it consists of the association cortex areas Brodmann area 11, 12 and 13; in humans it consists of Brodmann area 10, 11 and 47.

The OFC is functionally related to the ventromedial prefrontal cortex. Therefore, the region is distinguished due to the distinct neural connections and the distinct functions it performs. It is defined as the part of the prefrontal cortex that receives projections from the medial dorsal nucleus of the thalamus, and is thought to represent emotion, taste, smell and reward in decision-making. It gets its name from its position immediately above the orbits in which the eyes are located. Considerable individual variability has been found in the OFC of humans. A related area is found in rodents.