Philip the Handsome in the context of "County of Artois"

Charles V (24 February 1500 – 21 September 1558) was Holy Roman Emperor and Archduke of Austria from 1519 to 1556, King of Spain (as Charles I) from 1516 to 1556, King of Sicily and Naples from 1516 to 1554, and also Lord of the Netherlands and titular Duke of Burgundy (as Charles II) from 1506 to 1555. He was heir to and then head of the rising House of Habsburg. His dominions in Europe included the Holy Roman Empire, extending from Germany to northern Italy with rule over the Austrian hereditary lands and Burgundian Low Countries, and Spain with its possessions of the southern Italian kingdoms of Sicily, Naples, and Sardinia. In the Americas, he oversaw the continuation of Spanish colonization and a short-lived German colonization. The personal union of the European and American territories he ruled was the first collection of realms labelled "the empire on which the sun never sets".

Charles was born in Flanders to Habsburg Archduke Philip the Handsome, son of Maximilian I, Holy Roman Emperor and Mary of Burgundy, and Joanna of Castile, younger child of Isabella I of Castile and Ferdinand II of Aragon, the Catholic Monarchs of Spain. Heir of his grandparents, Charles inherited his family dominions at a young age. After his father's death in 1506, he inherited the Habsburg Netherlands in the Low Countries. In 1516 he became King of Spain as co-monarch of Castile and Aragon with his mother. Spain's possessions included the Castilian colonies of the West Indies and the Spanish Main, as well as Naples, Sicily, and Sardinia. At the death of his grandfather Maximilian in 1519, he inherited the Austrian hereditary lands and was elected as Holy Roman Emperor. He adopted the Imperial name of Charles V as his main title, and styled himself as a new Charlemagne.

Habsburg Netherlands were the parts of the Low Countries that were ruled by sovereigns from the House of Habsburg. Their rule began in 1482 and ended for the Northern Netherlands in 1581 and for the Southern Netherlands in 1797. Habsburg rule began with the accession of Philip the Handsome in 1482, when he succeeded his mother Mary of Burgundy of the House of Valois-Burgundy, who was the ruler of the Low Countries. Philip's son and heir Charles, future King of Spain (1516), and the Holy Roman Emperor (1519), was born in the Habsburg Netherlands and made Brussels one of his capitals.

During the Habsburg era, from 1482 to 1797, parts of the Netherlands under their rule went through various political changes and administrative reorganizations. Becoming known as the Seventeen Provinces in 1549, they were held by the Spanish branch of the Habsburgs from 1556, thus becoming known as the Spanish Netherlands from that time on. In 1581, in the midst of the Dutch Revolt, the Seven United Provinces seceded from the rest of this territory to form the Dutch Republic. The remaining Spanish Southern Netherlands became the Austrian Netherlands in 1714, after Austrian acquisition under the Treaty of Rastatt. De facto Habsburg rule ended with the annexation by the revolutionary French First Republic in 1795. Austria, however, did not relinquish its claim over the country until 1797 in the Treaty of Campo Formio.

The Burgundian Netherlands were those parts of the Low Countries that were ruled by the House of Valois-Burgundy between 1384 and 1482. During the Burgundian Age, those lands were also parts of the wider Valois-Burgundian State, which itself belonged, in terms of suzerainty, partly to the Kingdom of France and partly to the Holy Roman Empire. The Valois Dukes of Burgundy gradually acquired and united those lowlands into a political union that went beyond a personal union establishing central institutions for the first time (such as the States General).

The period began with Duke Philip the Bold taking office as count and lord of Antwerp, Artois, Flanders, Mechelen, and Rethel in 1384, and lasted until the death of Duchess Mary of Burgundy in 1482, after which the Valois-Burgundian State was dissolved, as Mary's titles and lands were inherited by her son Philip the Handsome, from the House of Habsburg, thus initiating creation of the Habsburg Netherlands.

Maximilian I (22 March 1459 – 12 January 1519) was King of the Romans from 1486 and Holy Roman Emperor from 1508 until his death in 1519. He was never crowned by the Pope, as the journey to Rome was blocked by the Venetians. He proclaimed himself elected emperor in 1508 at Trent, with Pope Julius II later recognizing it. This broke the tradition of requiring a papal coronation for the adoption of the Imperial title. Maximilian was the only surviving son of Frederick III, Holy Roman Emperor, and Eleanor of Portugal. From his coronation as King of the Romans in 1486, he ran a double government, or Doppelregierung with his father until Frederick's death in 1493.

Maximilian expanded the influence of the House of Habsburg through war and his marriage in 1477 to Mary, Duchess of Burgundy. However, he also lost his family's lands in Switzerland to the Swiss Confederacy. Through the marriage of his son Philip the Handsome to eventual queen Joanna of Castile in 1496, Maximilian helped to establish the Habsburg dynasty in Spain, which allowed his grandson Charles to hold the thrones of both Castile and Aragon. Historian Thomas A. Brady Jr. describes him as "the first Holy Roman Emperor in 250 years who ruled as well as reigned" and the "ablest royal warlord of his generation".

Joanna of Castile (6 November 1479 – 12 April 1555), historically known as Joanna the Mad (Spanish: Juana la Loca), was the nominal queen of Castile from 1504 and queen of Aragon from 1516 to her death in 1555. She was the daughter of Queen Isabella I of Castile and King Ferdinand II of Aragon. Joanna was married by arrangement to the Austrian archduke Philip the Handsome on 20 October 1496. Following the deaths of her elder brother John, elder sister Isabella, and nephew Miguel between 1497 and 1500, Joanna became the heir presumptive to the crowns of Castile and Aragon. When her mother died in 1504, she became queen of Castile. Her father proclaimed himself governor and administrator of Castile.

In 1506, Joanna's husband Philip became king of Castile jure uxoris as Philip I, initiating the rule of the Habsburgs in the Spanish kingdoms. Philip died that same year. Despite being the ruling queen of Castile, Joanna had little effect on national policy during her reign as she was declared insane and confined in the Royal Palace in Tordesillas under the orders of her father, who ruled as regent until his death in 1516, when she inherited his kingdom as well. Her son Charles I became king, and during his reign Joanna was nominally co-monarch but remained confined until her death. Joanna died aged 75 in 1555, at which point her son Charles, the Holy Roman Emperor, became the sole ruler of Castile and Aragon.

The Treaty of Senlis concerning the Burgundian succession was signed at the French city of Senlis on 23 May 1493, between King Charles VIII of France and Maximilian I, at the time King of the Romans and future Holy Roman Emperor, who acted on behalf of his young son Philip the Handsome, the Habsburg claimant to the Burgundian inheritance. The treaty contained 48 clauses, dealing with various political, dynastic and territorial questions that were previously addressed by the Treaty of Arras (1482).