Perseus of Macedon in the context of "Mylae (Thessaly)"

The Antigonid dynasty (/ænˈtɪɡoʊnɪd/; Ancient Greek: Ἀντιγονίδαι) was a Macedonian Greek royal house which ruled the kingdom of Macedon during the Hellenistic period. Founded by Antigonus I Monophthalmus, a general and successor of Alexander the Great, the dynasty first came to power after the Battle of Salamis in 306 BC and ruled much of Hellenistic Greece from 294 until their defeat at the Battle of Pydna in 168 BC (Third Macedonian War), after which Macedon came under the control of the Roman Republic.

The wars of the Diadochi witnessed the fall of the Argead dynasty in Macedon resulting in a power vacuum, which the Antigonid and Antipatrid dynasties sought to occupy. The Antigonid family first rose to power when Demetrius I Poliorcetes, son of Antigonus I, ousted Cassander's governor of Athens in 306 BC giving his father control over a land spanning from the Aegean Sea to the Middle East. Despite the subsequent instability and loss of the Asian territory, the family managed to maintain its power in mainland Greece and the islands, with Antigonus II Gonatas ultimately solidifying Antigonid rule over Hellenistic Macedon –a territory also known as the Antigonid Empire. Antigonus III Doson further expanded Macedonian influence in southern Greece reestablishing the Hellenic Alliance with himself as the president. Under Philip V, Antigonid Macedon first came into conflict with Rome, which had become a decisive power in the eastern Mediterranean. In the second century BC, the last Antigonid king, Perseus, became known as the champion of Greek resistance against Rome, albeit Rome's control over Antigonid Greece began to steadily expand, culminating in the fall of the dynasty in 168.

The Fourth Macedonian War (150–148 BC) was fought between Macedon, led by the pretender Andriscus, and the Roman Republic. It was the last of the Macedonian Wars, and was the last war to seriously threaten Roman control of Greece until the First Mithridatic War sixty years later.

The last Macedonian king of the Antigonid dynasty, Perseus, had been defeated and dethroned by the Romans in the Third Macedonian War in 168 BC. In the aftermath of the war, Rome took indirect control of the region through a system of client states, and imposed harsh terms to prevent Macedon from becoming a powerful state again. This system was successful in maintaining Roman hegemony for nearly two decades, but broke down when Andriscus, a Greek who bore a resemblance to Perseus, claimed to be the former king's son and re-established the Macedonian Kingdom with Thracian troops.

Andriscus (Ancient Greek: Ἀνδρίσκος, Andrískos; fl. 154/153 BC – 146 BC), also often referenced as Pseudo-Philip, was a Greek pretender who became the last independent king of Macedon in 149 BC as Philip VI (Ancient Greek: Φίλιππος, Philipos), based on his claim of being Philip, a now-obscure son of the last legitimate Macedonian king, Perseus. His reign lasted just one year and was toppled by the Roman Republic during the Fourth Macedonian War.

Ancient sources generally agree that he was originally a fuller from Adramyttium in Aeolis in western Anatolia. Around 153 BC, his ancestry was supposedly revealed to him, upon which he travelled to the court of his claimed uncle, the Seleucid monarch Demetrius I Soter, to request assistance in claiming his throne. Demetrius refused and had him sent to Rome, where he was judged harmless and exiled to a city in Italy; he managed to escape, and after gathering support, primarily from Thrace, he launched an invasion of Macedon, defeating Rome's clients and establishing his rule as king. The Romans naturally reacted militarily, triggering war; after some initial successes, Andriscus was defeated and captured by the praetor Quintus Caecilius Metellus Macedonicus, who subdued Macedon once again.

Philip V (Greek: Φίλιππος, romanized: Philippos; 238–179 BC) was king of the ancient Greek kingdom of Macedon from 221 to 179 BC. Philip's reign was principally marked by the Social War in Greece (220-217 BC) and a struggle with the emerging power of the Roman Republic. He would lead Macedon against Rome in the First (212-205 BC) and Second (200-196 BC) Macedonian Wars. While he lost the latter, Philip later allied with Rome against Antiochus III in the Roman-Seleucid War. He died in 179 BC from illness after efforts to recover the military and economic condition of Macedonia and passed the throne onto his elder son, Perseus of Macedon.

The Third Macedonian War (171–168 BC) was a war fought between the Roman Republic and King Perseus of Macedon. In 179 BC, King Philip V of Macedon died and was succeeded by his ambitious son Perseus. He was anti-Roman and stirred anti-Roman feelings around Macedonia. In 172 BC, a Roman commission visited Perseus and required of him concessions which meant the extinction of his independence. Upon his refusal to comply with the demands they returned home and Rome declared war.

Most of the war was fought in Macedon as well as neighbouring Thessaly, where the Roman troops were stationed. After an inconclusive battle at Callinicus in 171 BC, and several years of campaigning, Rome decisively defeated the Macedonian forces at the Battle of Pydna in 168 BC, ending the war.

The first government of ancient Macedonia was established by the Argead dynasty of Macedonian kings during the Archaic period (8th–5th centuries BC). The early history of the ancient kingdom of Macedonia is obscure because of shortcomings in the historical record; little is known of governmental institutions before the reign of Philip II during the late Classical period (480–336 BC). These bureaucratic organizations evolved in complexity under his successor Alexander the Great and the subsequent Antipatrid and Antigonid dynasties of Hellenistic Greece (336–146 BC). Following the Roman victory in the Third Macedonian War over Perseus of Macedon in 168 BC, the Macedonian monarchy was abolished and replaced by four client state republics. After a brief revival of the monarchy in 150–148 BC, the Fourth Macedonian War resulted in another Roman victory and the establishment of the Roman province of Macedonia.

It is unclear if there was a formally established constitution dictating the laws, organization, and divisions of power in ancient Macedonia's government, although some tangential evidence suggests this. The king (basileus) served as the head of state and was assisted by his noble companions and royal pages. Kings served as the chief judges of the kingdom, although little is known about Macedonia's judiciary. The kings were also expected to serve as high priests of the nation, using their wealth to sponsor various religious cults. The Macedonian kings had command over certain natural resources such as gold from mining and timber from logging. The right to mint gold, silver, and bronze coins was shared by the central and local governments.

The Antigonid Macedonian army was the army that evolved from the ancient Greek kingdom of Macedonia in the period when it was ruled by the Antigonid dynasty from 276 BC to 168 BC. It was seen as one of the principal Hellenistic fighting forces until its ultimate defeat at Roman hands at the Battle of Pydna in 168 BC. However, there was a brief resurgence in 150-148 during the revolt of Andriscus, a supposed heir to Perseus.

Starting as just a mere handful of mercenary troops under Antigonus Gonatas in the 270s BC, the Antigonid army eventually became the dominant force in Hellenistic Greece, fighting campaigns against Epirus, the Aetolian League, Sparta, Athens, Rhodes and Pergamon, not to mention the numerous Thracian and Celtic tribes that threatened Macedon from the north.