Peace of Amasya in the context of Ottoman–Safavid War (1623–39)

The Kingdom of Kartli-Kakheti (Georgian: ქართლ-კახეთის სამეფო, romanized: kartl-k'akhetis samepo) was created in 1762 by the unification of the two eastern Georgian kingdoms of Kartli and Kakheti. From the early 16th century, according to the 1555 Peace of Amasya, these two kingdoms were under Iranian control. In 1744, Nader Shah granted the kingship of Kartli to Teimuraz II and that of Kakheti to his son Heraclius II, as a reward for their loyalty. When Nader Shah died in 1747, Teimuraz II and Heraclius II capitalized on the instability in Iran proper, and declared de facto independence. After Teimuraz II died in 1762, Heraclius succeeded him as ruler of Kartli, thus unifying the two kingdoms.

Heraclius was able, after centuries of Iranian suzerainty over Georgia, to guarantee the autonomy of his kingdom throughout the chaos that had erupted following Nader Shah's death. He became the new Georgian king of a politically united eastern Georgia for the first time in three centuries. Though Heraclius tendered his de jure submission to the newly established Zand dynasty quickly after the unification in 1762, the kingdom remained de facto autonomous for the next three decades to come. In 1783, Heraclius signed the Treaty of Georgievsk with the Russian Empire, by which he formally laid Kartli-Kakheti's investiture in the hands of the Russian monarch, and made the kingdom a Russian protectorate. Amongst others, this provided the nominal guarantee for protection against new Iranian attempts, or by any others, to (re)conquer or attack eastern Georgia. By the 1790s, a new strong Iranian dynasty, the Qajar dynasty, had emerged under Agha Mohammad Khan Qajar, which would prove pivotal in the history of the short-lived kingdom.

The Ottoman–Safavid War of 1532–1555 was one of the many military conflicts fought between the two arch rivals, the Ottoman Empire led by Suleiman the Magnificent, and the Safavid Empire led by Tahmasp I. Ottoman territorial gains were confirmed in the Peace of Amasya.

The Ottoman–Safavid War of 1623–1639 was a conflict fought between the Ottoman Empire and Safavid Iran, then the two major powers of Western Asia, over control of Mesopotamia.

After initial Safavid success in recapturing Baghdad and most of Ottoman Iraq, having lost it for 90 years, the war became a stalemate as the Safavids were unable to press further into the Ottoman Empire, and the Ottomans themselves were distracted by wars in Europe and weakened by internal turmoil. Eventually, the Ottomans were able to recover Baghdad, taking heavy losses in the final siege, and the signing of the Treaty of Zuhab ended the war in an Ottoman victory. Roughly speaking, the treaty restored the borders of 1555, with the Safavids keeping Daghestan, Shirvan, eastern Georgia, and Eastern Armenia, while western Georgia and Western Armenia decisively came under Ottoman rule. The eastern part of Samtskhe (Meskheti) was irrevocably lost to the Ottomans as well as Mesopotamia. Although parts of Mesopotamia were briefly retaken by the Iranians later on in history, notably during the reigns of Nader Shah (1736–1747) and Karim Khan Zand (1751–1779), it remained thenceforth in Ottoman hands until the aftermath of World War I.

Tahmasp I (Persian: طهماسب یکم, romanized: Ṭahmāsb or تهماسب یکم Tahmâsb; 22 February 1514 – 14 May 1576) was the second shah of Safavid Iran from 1524 until his death in 1576. He was the eldest son of Shah Ismail I and his principal consort, the Mawsillu princess Tajlu Khanum.

Tahmasp ascended the throne after the death of his father on 23 May 1524. The first years of Tahmasp's reign were marked by civil wars between the Qizilbash leaders until 1532, when he asserted his authority and began an absolute monarchy. He soon faced a long-lasting war with the Ottoman Empire, which was divided into three phases. The Ottoman sultan, Suleiman the Magnificent, tried to install his own candidates on the Safavid throne. The war ended with the Peace of Amasya in 1555, with the Ottomans gaining sovereignty over Iraq, much of Kurdistan, and western Georgia. Tahmasp also had conflicts with the Uzbeks of Bukhara over Khorasan, with them repeatedly raiding Herat. In 1528, at the age of fourteen, he defeated the Uzbeks in the Battle of Jam by using artillery.

The Battle of Chaldiran (Persian: جنگ چالدران; Turkish: Çaldıran Savaşı) took place on 23 August 1514 and ended with a decisive victory for the Ottoman Empire over the Safavid Empire. As a result, the Ottomans annexed Eastern Anatolia and Upper Mesopotamia from Safavid Iran. It marked the first Ottoman expansion into Eastern Anatolia, and the halt of the Safavid expansion to the west. The Battle of Chaldiran was just the beginning of 41 years of destructive war, which only ended in 1555 with the Peace of Amasya. Though the Safavids eventually reconquered Mesopotamia and Eastern Anatolia under the reign of Abbas the Great (r. 1588–1629), they would be permanently ceded to the Ottomans by the 1639 Treaty of Zuhab.

At Chaldiran, the Ottomans had a larger, better-equipped army numbering 60,000 to 100,000 and many heavy artillery pieces. In contrast, the Safavid army numbered 40,000 to 80,000 and did not have artillery. Ismail I, the leader of the Safavids, was wounded and almost captured during the battle. His wives were captured by the Ottoman leader Selim I, with at least one married off to one of Selim's statesmen. Ismail retired to his palace and withdrew from government administration after this defeat and never again participated in a military campaign. After their victory, Ottoman forces marched deeper into Persia, briefly occupying the Safavid capital Tabriz, and thoroughly looting the Persian imperial treasury.