Beginning with three synods convened between 264 and 269 in the matter of Paul of Samosata, more than thirty councils were held in Antioch in ancient times. Most of these dealt with phases of the Arian and of the Christological controversies. For example, the Catholic Encyclopedia article on Paul of Samosata states:
The most celebrated convened in the summer of 341 at the dedication of the Domus Aurea, and is therefore called in encaeniis or dedication council. Nearly a hundred Eastern bishops were present, but the bishop of Rome was not represented. The emperor Constantius II attended in person.