Paresthesia in the context of "Hyperkalemia"

Poliomyelitis (/ˌpoʊlioʊˌmaɪəˈlaɪtɪs/ POH-lee-oh-MY-ə-LY-tiss), commonly shortened to polio, is an infectious disease caused by the poliovirus. Approximately 75% of cases are asymptomatic; mild symptoms which can occur include sore throat and fever; in a proportion of cases more severe symptoms develop such as headache, neck stiffness, and paresthesia. These symptoms usually pass within one or two weeks. A less common symptom is permanent paralysis, and possible death in extreme cases. Years after recovery, post-polio syndrome may occur, with a slow development of muscle weakness similar to what the person had during the initial infection.

Polio occurs naturally only in humans. It is highly infectious, and is spread from person to person either through fecal–oral transmission (e.g. poor hygiene, or by ingestion of food or water contaminated by human feces), or via the oral–oral route. Those who are infected may spread the disease for up to six weeks even if no symptoms are present. The disease may be diagnosed by finding the virus in the feces or detecting antibodies against it in the blood.

Shingles, also known as herpes zoster or zona, is a viral disease characterized by a painful skin rash with blisters in a localized area. Typically the rash occurs in a single, wide mark either on the left or right side of the body or face. Two to four days before the rash occurs, there may be tingling or local pain in the area. Other common symptoms are fever, headache, and tiredness. The rash usually heals within two to four weeks, but some people develop ongoing nerve pain which can last for months or years, a condition called postherpetic neuralgia (PHN). In those with poor immune function the rash may occur widely. If the rash involves the eye, vision loss may occur.

Shingles is caused by the varicella zoster virus (VZV) that also causes chickenpox. In the case of chickenpox, also called varicella, the initial infection with the virus typically occurs during childhood or adolescence. Once the chickenpox has resolved, the virus can remain dormant (inactive) in human nerve cells (dorsal root ganglia or cranial nerves) for years or decades, after which it may reactivate and travel along nerve bodies to nerve endings in the skin, producing blisters. During an outbreak of shingles, exposure to the varicella virus found in shingles blisters can cause chickenpox in someone who has not yet had chickenpox, although that person will not suffer from shingles, at least on the first infection. How the virus remains dormant in nerve cells or subsequently re-activates is not well understood.

Deities in ancient Mesopotamia were almost exclusively anthropomorphic. They were thought to possess extraordinary powers and were often envisioned as being of tremendous physical size. The deities typically wore melam, an ambiguous substance which "covered them in terrifying splendor" and which could also be worn by heroes, kings, giants, and even demons. The effect that seeing a deity's melam has on a human is described as ni, a word for the "physical creeping of the flesh". Both the Sumerian and Akkadian languages contain many words to express the sensation of ni, including the word puluhtu, meaning "fear". Deities were almost always depicted wearing horned caps, consisting of up to seven superimposed pairs of ox-horns. They were also sometimes depicted wearing clothes with elaborate decorative gold and silver ornaments sewninto them.

The ancient Mesopotamians believed that their deities lived in Heaven, but that a god's statue was a physical embodiment of the god himself. As such, cult statues were given constant care and attention and a set of priests were assigned to tend to them. These priests would clothe the statues and place feasts before them so they could "eat". A deity's temple was believed to be that deity's literal place of residence. The gods had boats, full-sized barges which were normally stored inside their temples and were used to transport their cult statues along waterways during various religious festivals. The gods also had chariots, which were used for transporting their cult statues by land. Sometimes a deity's cult statue would be transported to the location of a battle so that the deity could watch the battle unfold. The major deities of the Mesopotamian pantheon were believed to participate in the "assembly of the gods", through which the gods made all of their decisions. This assembly was seen as a divine counterpart to the semi-democratic legislative system that existed during the Third Dynasty of Ur (c. 2112 BC – c. 2004 BC).

Postherpetic neuralgia (PHN) is neuropathic pain that occurs due to damage to a peripheral nerve caused by the reactivation of the varicella zoster virus (herpes zoster, also known as shingles). PHN is defined as pain in a dermatomal distribution that lasts for at least 90 days after an outbreak of herpes zoster. Several types of pain may occur with PHN including continuous burning pain, episodes of severe shooting or electric-like pain, and a heightened sensitivity to gentle touch which would not otherwise cause pain or to painful stimuli. Abnormal sensations and itching may also occur.

Postherpetic neuralgia is the most common long-term complication of herpes zoster, and occurs in approximately 20% of patients with shingles. Risk factors for PHN include older age, severe prodrome or rash, severe acute zoster pain, ophthalmic involvement, immunosuppression, and chronic conditions such as diabetes mellitus and lupus. The pain from postherpetic neuralgia can be very severe and debilitating. There is no treatment which modifies the course of the disease and management primarily aims to control symptoms. Affected individuals often experience a decrease in their quality of life.