Palaeotherium is an extinct genus of equoid that lived in Europe and possibly the Middle East from the Middle Eocene to the Early Oligocene. It is the type genus of the Palaeotheriidae, a group exclusive to the Palaeogene that was closest in relation to the Equidae, which contains horses plus their closest relatives and ancestors. Fossils of Palaeotherium were first described in 1782 by the French naturalist Robert de Lamanon and then closely studied by another French naturalist, Georges Cuvier, after 1798. Cuvier erected the genus in 1804 and recognized multiple species based on overall fossil sizes and forms. As one of the first fossil genera to be recognized with official taxonomic authority, it is recognized as an important milestone within the field of palaeontology. The research by early naturalists on Palaeotherium contributed to the developing ideas of evolution, extinction, and succession and demonstrating the morphological diversity of different species within one genus.
Since Cuvier's descriptions, many other naturalists from Europe and the Americas recognized many species of Palaeotherium, some valid, some reclassified to different genera afterward, and others being eventually rendered invalid. The German palaeontologist Jens Lorenz Franzen modernized its taxonomy due to his recognition of many subspecies as part of his dissertation in 1968, which were subsequently accepted by other palaeontologists. Today, there are sixteen known species recognized, many of which have multiple subspecies. In 1992, the French palaeontologist Jean-Albert Remy recognized two subgenera that most species are classified to based on cranial anatomies: the specialized Palaeotherium and the more generalized Franzenitherium.