The Oto-Manguean or Otomanguean (/ˌoʊtoʊˈmæŋɡiːən/ OH-to-MANG-ghee-ən) languages are a large family comprising several subfamilies of indigenous languages of the Americas. All of the Oto-Manguean languages that are now spoken are indigenous to Mexico, but the Manguean branch of the family, which is now extinct, was spoken as far south as Nicaragua and Costa Rica. Oto-Manguean is widely viewed as a proven language family.
The highest number of speakers of Oto-Manguean languages today are found in the state of Oaxaca where the two largest branches, the Zapotecan and Mixtecan languages, are spoken by almost 1.5 million people combined. In central Mexico, particularly in the states of Mexico, Hidalgo and Querétaro, the languages of the Oto-Pamean branch are spoken: the Otomi and the closely related Mazahua have over 500,000 speakers combined. In the linguistic world of Mesoamerica, the Otomanguean family stands out as the most diverse and extensively distributed.