O'Higgins Region in the context of Central Valley (Chilean wine region)

Pichilemu (Mapudungun: Small forest, pronounced [pitʃiˈlemu] ), originally known as Pichilemo, is a beach resort city and commune in central Chile, and capital of Cardenal Caro Province in the O'Higgins Region. The commune comprises an urban centre and twenty-two villages, including Ciruelos, Cáhuil, and Cardonal de Panilonco. It is located southwest of Santiago. Pichilemu had over 13,000 residents as of 2012.

The Pichilemu area was long populated by the indigenous Promaucaes. European-Chilean development began in the mid-sixteenth century, as conquistador Pedro de Valdivia gave Juan Gómez de Almagro the Topocalma encomienda (which included the current territory of Pichilemu) in January 1541. Pichilemu was established as a subdelegation on 16 August 1867, and later as an "autonomous commune" on 22 December 1891, by decree of the President Jorge Montt and Interior Minister Manuel José Irarrázabal. Agustín Ross Edwards, a Chilean politician and member of the Ross Edwards family, planned to develop it as a beach resort on the Pacific Ocean for upper-class Chileans.

32°S 70°W / 32°S 70°W / -32; -70

Principal Cordillera (Spanish: Cordillera Principal) is the Andean mountain range that makes up the boundary between Central Chile and neighbouring areas of Argentina. It is also a continental divide between the Atlantic and the Pacific watersheds. It extends in a north–south direction in the Argentine provinces of La Rioja, San Juan and Mendoza and the Chilean regions of Valparaíso, Santiago, O'Higgins and Maule. To the east of the Principal Cordillera lies the Frontal Cordillera which is fully in Argentina. Aconcagua, the tallest mountain outside Asia, lies in the Principal Cordillera.

Fundición Caletones or simply Caletones is a copper smelter plant in the Andes of Central Chile in Chile's O'Higgins Region in the Machalí commune. The smelter is integrated with the nearby copper mine of El Teniente, and both are owned by Codelco. After a failed attempt in the 1960s to expand the capacity using Peirce Smith converters (PSC) Caletones developed its own smelting technology becoming the birthplace of the Teniente Converter (TC), the first of which began operations in 1977.

At present Caletones has the capacity to each year process 1360 to 1400 kTon of concentrates and to produce 400 to 435 kTon cathode copper. As of 2015 it ranked second in Chile and among the 20 largest copper smelters in the world in terms of production capacity.

Cáhuil (Mapudungun: Place of seagulls, pronounced [ˈkawil] ) is a Chilean village located 15 kilometres (9.3 mi) south of Pichilemu, at the mouth of the seasonal Nilahue Estuary, in the O'Higgins Region. Its economy is based on the production of sea salt, oysters, and mussels. The estuary is suitable for fishing, swimming, and boating.

Santa Cruz is a Chilean city and commune, located in the Colchagua valley, in the O'Higgins Region, located on the southern shore of the Tinguiririca river, 110 miles from Santiago, Chile's capital city, and 27 miles from San Fernando.

Rancagua (Spanish pronunciation: [raŋˈkaɣwa]) is a city and commune in central Chile and part of the Rancagua conurbation. It is the capital of the Cachapoal Province and of the O'Higgins Region, located 87 km (54 mi) south of the national capital of Santiago.

It was originally named Santa Cruz de Triana by Spanish colonists. In 2012, its population was 232,211. The main economic activities range from mining, tourism, agriculture, timber, food production and services to minor industrial activities. The city also serves as the administrative and legal center of the region.