In England, the term North–South divide refers to the cultural, economic, and social differences between Southern England and Northern England:
- Southern England usually refers to South East England, South West England and in some definitions, The East Of England, including Greater London.
- Northern England usually refers to North East England, Yorkshire and the Humber and North West England including Merseyside and Greater Manchester.
There is also the central region of the Midlands which historically was administered by the Kingdom of Mercia whose borders were defined by the Mersey, the Humber, the Severn and the Thames as shown by its flag, a saltire cross. Counties in the north of the area, such as Derbyshire, Leicestershire, Lincolnshire, Nottinghamshire, Rutland and Staffordshire are sometimes seen as Northern. A grouping of "Central England" based on European parliamentary constituency boundaries combined the Midlands and East Anglia until the United Kingdom's departure from the European Union in January 2020.