The North Wales Main Line (Welsh: Prif Linell Gogledd Cymru or Prif Linell y Gogledd; lit. 'north main line'), also known as the North Wales Coast Line (Welsh: Llinell Arfordir Gogledd Cymru), is a major railway line in the north of Wales and Cheshire, England, running from Crewe on the West Coast Main Line to Holyhead on the Isle of Anglesey. The line has 19 stations, with all except two, Chester and Crewe, being in Wales.
The line is not currently electrified, so Avanti West Coast, the current operator of the West Coast Partnership franchise, currently uses Class 805 Evero units. Class 221 Super Voyagers were previously used from December 2007 to December 2024. Plans to electrify the line were announced in October 2023.