Non-binary gender in the context of Gender Identity

A transgender (often shortened to trans) person has a gender identity different from that typically associated with the sex they were assigned at birth. The opposite of transgender is cisgender, which describes persons whose gender identity matches their assigned sex.

Many transgender people desire medical assistance to medically transition from one sex to another; those who do may identify as transsexual. Transgender does not have a universally accepted definition, including among researchers; it can function as an umbrella term. The definition given above includes binary trans men and trans women and may also include people who are non-binary or genderqueer. Other related groups include third-gender people, cross-dressers, and drag queens and drag kings; some definitions include these groups as well.

Gender identity is the personal sense of one's own gender. Gender identity can correlate with a person's assigned sex or can differ from it. In most individuals, the various biological determinants of sex are congruent and consistent with the individual's gender identity. Gender expression typically reflects a person's gender identity, but this is not always the case. While a person may express behaviors, attitudes, and appearances consistent with a particular gender role, such expression may not necessarily reflect their gender identity. The term gender identity was coined by psychiatry professor Robert J. Stoller in 1964 and popularized by psychologist John Money.

In most societies, there is a basic division between gender attributes associated with males and females, a gender binary to which most people adhere and which includes expectations of masculinity and femininity in all aspects of sex and gender: biological sex, gender identity, gender expression, and sexual orientation. Some people do not identify with some, or all, of the aspects of gender associated with their biological sex; some of those people are transgender, non-binary, or genderqueer. Some societies have third gender categories.

Sexual and gender minorities (SGM) comprise individuals whose sexual identity, sexual orientation, sexual behavior, or gender identity differ from the majority of the surrounding society. Sexual minorities include lesbians, gay men, bisexual people, asexual people, and other non-heterosexual people, Gender minorities include transgender people, non-binary (including third gender), and intersex individuals. Gender, sexual and romantic minorities (GSRM) includes individuals of a minority romantic orientation such as aromanticism.

Sexual and gender minorities includes LGBTQ people as well as those who do not identify as LGBTQ. In 2015, the United States National Institutes of Health described SGM as an "umbrella term that encompasses populations included in the acronym "LGBTI" (lesbian, gay, bisexual, transgender and intersex), and those whose sexual orientation or gender identity varies. It includes those who may not self-identify as LGBTI (e.g., queer, questioning, two-spirit, asexual, men who have sex with men, women who have sex with women, gender variant), or those who have a specific medical condition affecting reproductive development (e.g., individuals with differences or disorders of sex development, who sometimes identify as intersex)."

In behavioral science, androphilia and gynephilia are sexual orientations: Androphilia is sexual attraction to men and/or masculinity; gynephilia is sexual attraction to women and/or femininity. Ambiphilia describes the combination of both androphilia and gynephilia in a given individual, or bisexuality. The terms offer an alternative to a gender binary homosexual and heterosexual conceptualization of sexuality.

The terms are used for identifying a person's objects of attraction without attributing a sex assignment or gender identity to the person. They may be used when describing intersex, transgender, and non-binary people.

Gender fluidity (commonly referred to as genderfluid) is a non-fixed gender identity that shifts over time or depending on the situation. These fluctuations can occur at the level of gender identity or gender expression. A genderfluid person may fluctuate among different gender expressions over their lifetime, or express multiple aspects of various gender markers simultaneously. Genderfluid individuals may identify as non-binary, transgender, or cisgender (meaning they identify with the gender associated with their sex assigned at birth).

Gender fluidity is different from gender-questioning, a process in which people explore their gender in order to find their true gender identity and adjust their gender expression accordingly. Gender fluidity continues throughout lives of genderfluid people. Someone who identifies as genderfluid can use any pronouns they choose.

Gynaecology (or gynecology in American English) is the area of medicine concerned with conditions affecting the female reproductive system. It is sometimes combined with the field of obstetrics, which focuses on pregnancy and childbirth, thereby forming the combined area of obstetrics and gynaecology (OB-GYN).

Gynaecology encompasses preventative care, sexual health and diagnosing and treating health issues arising from the female reproduction system, such as the uterus, vagina, cervix, fallopian tubes, ovaries, and breasts; subspecialties include family planning; minimally invasive surgery; paediatric and adolescent gynaecology; and pelvic medicine and reconstructive surgery. Transgender, intersex and nonbinary individuals can in some instances require gynaecological care.

Legal gender, or legal sex, is a sex or gender that is recognized under the law. Biological sex, sex reassignment and gender identity are used to determine legal gender. The details vary by jurisdiction. Legal gender identity is fundamental to many legal rights and obligations, including access to healthcare, work, and family relationships, as well as issues of personal identification and documentation. The complexities involved in determining legal gender, despite the seeming simplicity of the underlying principles, highlight the dynamic interaction between biological characteristics, self-identified gender identity, societal norms, and changing legal standards. Because of this, the study of legal gender is a complex field that is influenced by cultural, historical, and legal factors. As such, a thorough investigation is necessary to fully understand the subject's implications and breadth within a range of legal systems and societies.

Mount Holyoke College is a private women's liberal arts college in South Hadley, Massachusetts, United States. It is the oldest member of the historic Seven Sisters colleges, a group of historically women’s colleges in the Northeastern United States. The college was founded in 1837 as the Mount Holyoke Female Seminary by Mary Lyon, a pioneer in education for women. Mount Holyoke is part of the Five College Consortium in Western Massachusetts.

Undergraduate admissions are restricted to female, transgender, and nonbinary students. In 2014, it became the first member of the Seven Sisters (not counting the coeducational Vassar College) to introduce an admissions policy that was inclusive of transgender students. Graduate programs are open to applicants regardless of gender.

Wellesley College is a private women's liberal arts college in Wellesley, Massachusetts, United States. Founded in 1870 by Henry and Pauline Durant as a female seminary, it is a member of the Seven Sisters Colleges, an unofficial grouping of women's colleges in the northeastern United States.

Wellesley enrolls approximately 2,500 students, including transgender, non-binary and genderqueer students since 2015. It contains 60 departmental and interdepartmental majors spanning the liberal arts, as well as over 150 student clubs and organizations. Wellesley athletes compete in the NCAA Division III New England Women's and Men's Athletic Conference. Its 500-acre (200 ha) campus was designed by Frederick Law Olmsted and houses the Davis Museum and a botanic garden.

Feminizing hormone therapy, also known as transfeminine hormone therapy, is a form of gender-affirming care and a gender-affirming hormone therapy to change the secondary sex characteristics of transgender people from masculine to feminine. It is a common type of transgender hormone therapy (another being masculinizing hormone therapy) and is used to treat transgender women and non-binary transfeminine individuals. Some, in particular intersex people, but also some non-transgender people, take this form of therapy according to their personal needs and preferences.

The purpose of the therapy is to cause the development of the secondary sex characteristics of the desired sex, such as breasts and a feminine pattern of hair, fat, and muscle distribution. It cannot undo many of the changes produced by naturally occurring puberty, which may necessitate surgery and other treatments to reverse (see below). The medications used for feminizing hormone therapy include estrogens, antiandrogens, progestogens, and gonadotropin-releasing hormone modulators (GnRH modulators).

Estradiol (E2) is a medication and naturally occurring steroid hormone. It is an estrogen and is used mainly in menopausal hormone therapy and to treat low sex hormone levels in women. It is also used in hormonal birth control for women, in feminizing hormone therapy for transgender women and some non-binary individuals, and in the treatment of hormone-sensitive cancers like prostate cancer in men and breast cancer in women, among other uses. Estradiol can be taken by mouth, held and dissolved under the tongue, as a gel or patch that is applied to the skin, in through the vagina, by injection into muscle or fat, or through the use of an implant that is placed into fat, among other routes.

Side effects of estradiol in women include breast tenderness, breast enlargement, headache, fluid retention, and nausea among others. Men and children who are exposed to estradiol may develop symptoms of feminization, such as breast development and a feminine pattern of fat distribution, and men may also experience low testosterone levels and infertility. Estradiol may increase the risk of endometrial hyperplasia and endometrial cancer in women with intact uteruses if it is not taken together with a progestogen such as progesterone. The combination of estradiol with a progestin, though not with oral progesterone, may increase the risk of breast cancer. Estradiol should not be used in women who are pregnant or breastfeeding or who have breast cancer, among other contraindications.