Nidāna (निदान) is a Sanskrit and Pali word that means "cause, motivation or occasion" depending on the context. The word is derived from the Sanskrit prefix ni- (नि; "down", "into") plus the root dā (दा; "to bind"), forming the verb nidā (निदा; "to bind on, fasten"). This in turn yields the noun nidāna (निदान; lit. "a band, rope or halter"). It appears in the Rigveda, such as hymn 10.114.2, and other Hindu scriptures, wherein it means "primary or first cause, linked cause"; in other contexts such as Rigveda 6.32.6, nidāna refers to the literal meaning of a rope or band that links, binds or fastens one thing to another, such as a horse to a cart. The word has been borrowed into modern languages such as Hindi and Marathi to mean "diagnosis" or "primary cause" among others.
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Nidāna in the context of Dependent origination
Pratītyasamutpāda (Sanskrit: प्रतीत्यसमुत्पाद, Pāli: paṭiccasamuppāda), commonly translated as dependent origination, or dependent arising, is a key doctrine in Buddhism shared by all schools of Buddhism. It states that all dharmas (phenomena) arise in dependence upon other dharmas: "if this exists, that exists; if this ceases to exist, that also ceases to exist". The basic principle is that all things (dharmas, phenomena, principles) arise in dependence upon other things.
The doctrine includes depictions of the arising of suffering (anuloma-paṭiccasamuppāda, "with the grain", forward conditionality) and depictions of how the chain can be reversed (paṭiloma-paṭiccasamuppāda, "against the grain", reverse conditionality). These processes are expressed in various lists of dependently originated phenomena, the most well-known of which is the twelve links or nidānas (Pāli: dvādasanidānāni, Sanskrit: dvādaśanidānāni). The traditional interpretation of these lists is that they describe the process of a sentient being's rebirth in saṃsāra, and the resultant duḥkha (suffering, pain, unsatisfactoriness), and they provide an analysis of rebirth and suffering that avoids positing an atman (unchanging self or eternal soul). The reversal of the causal chain is explained as leading to the cessation of rebirth (and thus, the cessation of suffering).