Nicholas Ulrich Mayall (May 9, 1906 – January 5, 1993) was an American observational astronomer. After obtaining his doctorate from the University of California, Berkeley, Mayall worked at the Lick Observatory, where he remained from 1934 to 1960, except for a brief period at MIT's Radiation Laboratory during World War II.
During his time at Lick, Mayall contributed to astronomical knowledge of nebulae, supernovae, spiral galaxy internal motions, the redshifts of galaxies, and the origin, age, and size of the Universe. He played a significant role in the planning and construction of Lick's 120-inch (3.0 m) reflector, which represented a major improvement over its earlier 36-inch (0.91 m) telescope.