New River (Kanawha River) in the context of Gauley River

The Potomac Highlands of West Virginia (/pəˈtoʊmək/ ), or simply the Potomac Highlands, centers on five West Virginian counties (Grant, Hampshire, Hardy, Mineral, and Pendleton) in the upper Potomac River watershed in the western portion of the state's eastern panhandle, bordering Maryland and Virginia. Because of geographical proximity, similar topography and landscapes, and shared culture and history, the Potomac Highlands region is also considered to include Pocahontas, Randolph, and Tucker Counties, even though they are in the Monongahela River or New River watersheds and not the Potomac River watershed.

The Potomac Highlands broadly overlap but are not identical with the four-state Allegheny Highlands or High Alleghenies region, which includes the relatively high and rugged mountains along and near the Allegheny Front from extreme southern Pennsylvania southward across Maryland and West Virginia into adjacent Virginia.

The New River Gorge National Park and Preserve is a United States national park and preserve designed to protect and maintain the New River Gorge in southern West Virginia in the Appalachian Mountains. Established in 1978 as a national river and redesignated in 2020, the park and preserve stretches for 53 miles (85 km) from just downstream of Hinton to Hawks Nest State Park near Ansted.

The park is rich in cultural and natural history and offers an abundance of scenic and recreational opportunities. New River Gorge has some of the country's best whitewater rafting, mainly from the Cunard put-in to the Fayette Station take-out, and is also one of the most popular climbing areas on the East Coast. The New River itself originates in North Carolina, flowing north through Virginia into the West Virginia mountains to the Kanawha River which continues to the Ohio River.

The Kanawha River (/kəˈnɔːə/ kə-NAW-ə) is a tributary of the Ohio River, approximately 97 mi (156 km) long, in the U.S. state of West Virginia. The largest inland waterway in West Virginia, its watershed has been a significant industrial region of the state since early in the 19th century.

It is formed at the town of Gauley Bridge in northwestern Fayette County, approximately 35 mi (56 km) SE of Charleston, by the confluence of the New and Gauley rivers 2 mi upstream from Kanawha Falls. The waterfall is 24 ft high and has been a barrier to fish movement for more than 1 million years. The river flows generally northwest, in a winding course on the unglaciated Allegheny Plateau, through Fayette, Kanawha, Putnam, and Mason counties, past the cities of Charleston and St. Albans, and numerous smaller communities. It joins the Ohio at Point Pleasant. An environmental overview and summary of natural and human factors affecting water quality in the watershed was published in 2000.

Virginia's New River Valley region, colloquially named, is a four-county area along the New River in Southwest Virginia in the United States, including such major features as Claytor Lake, part of the Jefferson National Forest, the city of Radford, the town of Blacksburg, and the river itself, including the Pulaski terminus of the New River Trail State Park.

Local TV stations and tourism marketing promoters use the phrase to mean the counties of Giles, Pulaski, Montgomery and Floyd, the towns within them (e.g., Blacksburg), and the independent City of Radford, all located in the New River watershed. While Floyd County is not on the New River itself, it shares the Little River (New River tributary) with Montgomery and Pulaski.