Neuroplasticity in the context of Neurogenesis

Developmental psychology is the scientific study of how and why humans grow, change, and adapt across the course of their lives. Originally concerned with infants and children, the field has expanded to include adolescence, adult development, aging, and the entire lifespan. Developmental psychologists aim to explain how thinking, feeling, and behaviors change throughout life. This field examines change across three major dimensions, which are physical development, cognitive development, and social emotional development. Within these three dimensions are a broad range of topics including motor skills, executive functions, moral understanding, language acquisition, social change, personality, emotional development, self-concept, and identity formation.

Developmental psychology explores the influence of both nature and nurture on human development, as well as the processes of change that occur across different contexts over time. Many researchers are interested in the interactions among personal characteristics, the individual's behavior, and environmental factors, including the social context and the built environment. Ongoing debates in regards to developmental psychology include biological essentialism vs. neuroplasticity and stages of development vs. dynamic systems of development. While research in developmental psychology has certain limitations, ongoing studies aim to understand how life stage transitions and biological factors influence human behavior and development.

Neurotherapy is medical treatment that implements systemic targeted delivery of an energy stimulus or chemical agents to a specific neurological zone in the body to alter neuronal activity and stimulate neuroplasticity in a way that develops (or balances) a nervous system in order to treat different diseases, restore and/or to improve patients' physical strength, cognitive functions, and overall health.

Addiction is a neuropsychological disorder characterized by a persistent and intense urge to use a drug or engage in a behavior that produces natural reward, despite substantial harm and other negative consequences. Repetitive drug use can alter brain function in synapses similar to natural rewards like food or falling in love in ways that perpetuate craving and weakens self-control for people with pre-existing vulnerabilities. This phenomenon – drugs reshaping brain function – has led to an understanding of addiction as a brain disorder with a complex variety of psychosocial as well as neurobiological factors that are implicated in the development of addiction. While mice given cocaine showed the compulsive and involuntary nature of addiction, for humans this is more complex, related to behavior or personality traits.

Classic signs of addiction include compulsive engagement in rewarding stimuli, preoccupation with substances or behavior, and continued use despite negative consequences. Habits and patterns associated with addiction are typically characterized by immediate gratification (short-term reward), coupled with delayed deleterious effects (long-term costs).

Cat intelligence refers to a cat’s ability to solve problems, adapt to its environment, learn new behaviors, and communicate its needs. Structurally, a cat’s brain shares similarities with the human brain, containing around 250 million neurons in the cerebral cortex, which is responsible for complex processing. Cats display neuroplasticity, allowing their brains to reorganize based on experiences. They have well-developed memory retaining information for a decade or longer. These memories are often intertwined with emotions, allowing cats to recall both positive and negative experiences associated with specific places. While they excel in observational learning and problem-solving, studies conclude that they struggle with understanding cause-and-effect relationships in the same way that humans do.

The study of cat intelligence is mostly focused on domesticated cats. Living in urban environments has exposed them to challenges that require adaptive behaviors, contributing to cognitive development. Selective breeding and genetic changes have further influenced their intelligence. Kittens learn essential survival skills by observing their mothers, while adult cats refine their abilities through trial and error.

Activity-dependent plasticity is a form of functional and structural neuroplasticity that arises from the use of cognitive functions and personal experience. Hence, it is the biological basis for learning and the formation of new memories. Activity-dependent plasticity is a form of neuroplasticity that arises from intrinsic or endogenous activity, as opposed to forms of neuroplasticity that arise from extrinsic or exogenous factors, such as electrical brain stimulation- or drug-induced neuroplasticity. The brain's ability to remodel itself forms the basis of the brain's capacity to retain memories, improve motor function, and enhance comprehension and speech amongst other things. It is this trait to retain and form memories that is associated with neural plasticity and therefore many of the functions individuals perform on a daily basis. This plasticity occurs as a result of changes in gene expression which are triggered by signaling cascades that are activated by various signaling molecules (e.g., calcium, dopamine, and glutamate, among many others) during increased neuronal activity.

The brain's ability to adapt toward active functions allows humans to specialize in specific processes based on relative use and activity. For example, a right-handed person may perform any movement poorly with their left hand but continuous practice with the non-dominant hand can cause one to become ambidextrous.

Developmental psychology is the scientific study of how and why humans grow, change, and adapt across the course of their lives. Originally concerned with infants and children, the field has expanded to include adolescence, adult development, aging, and the entire lifespan. Developmental psychologists aim to explain how thinking, feeling, and behaviors change throughout life. This field examines change across three major dimensions, which are physical development, cognitive development, and social emotional development. Within these three dimensions are a broad range of topics including motor skills, executive functions, moral understanding, language acquisition, social change, personality, emotional development, self-concept, and identity formation.

Developmental psychology explores the influence of both nature and nurture on human development, as well as the processes of change that occur across different contexts over time. Many researchers are interested in the interactions among personal characteristics, the individual's behavior, and environmental factors, including the social context and the built environment. Ongoing debates in regards to developmental psychology include biological essentialism vs. neuroplasticity, and stages of development vs. dynamic systems of development. While research in developmental psychology has certain limitations, ongoing studies aim to understand how life stage transitions and biological factors influence human behavior and development.

Molecular neuroscience is a branch of neuroscience that observes concepts in molecular biology applied to the nervous systems of animals. The scope of this subject covers topics such as molecular neuroanatomy, mechanisms of molecular signaling in the nervous system, the effects of genetics and epigenetics on neuronal development, and the molecular basis for neuroplasticity and neurodegenerative diseases. As with molecular biology, molecular neuroscience is a relatively new field that is considerably dynamic.

Myelination, or myelinogenesis, is the formation and development of myelin sheaths in the nervous system, typically initiated in late prenatal neurodevelopment and continuing throughout postnatal development. The term myelinogenesis is also sometimes used to differentiate the very early stages of embryonic myelination.

Myelin is formed by oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system. Myelination continues throughout the lifespan to support learning and memory via neural circuit plasticity as well as remyelination following injury. Successful myelination of axons increases action potential speed by enabling saltatory conduction, which is essential for timely signal conduction between spatially separate brain regions, as well as provides metabolic support to neurons.

Jon Kaas is a professor at Vanderbilt University and a member of the United States National Academy of Sciences. He has made discoveries about the organization of the mammalian brain, including the description of many areas of the cerebral cortex and their neuroplasticity.

Work from the Kaas's laboratory is notable for its emphasis on evolutionary biology. Kaas's approach is to try to understand how complex brains evolved from ancestor forms which had relatively few areas. Some of the career highlights include:

Pyramidal cells, or pyramidal neurons, are a type of multipolar neuron found in areas of the brain including the cerebral cortex, the hippocampus, and the amygdala. Pyramidal cells are the primary excitation units of the mammalian prefrontal cortex and the corticospinal tract. One of the main structural features of the pyramidal neuron is the conic shaped soma, or cell body, after which the neuron is named. Other key structural features of the pyramidal cell are a single axon, a large apical dendrite, multiple basal dendrites, and the presence of dendritic spines.

Pyramidal neurons are also one of two cell types where the characteristic sign, Negri bodies, are found in post-mortem rabies infection. Pyramidal neurons were first discovered and studied by Santiago Ramón y Cajal. Since then, studies on pyramidal neurons have focused on topics ranging from neuroplasticity to cognition.

Brain training (also known as a mental exercise or cognitive training) is a program of regular activities purported to maintain or improve one's cognitive abilities. The phrase "cognitive ability" usually refers to components of fluid intelligence such as executive function and working memory. Cognitive training reflects a hypothesis that cognitive abilities can be maintained or improved by exercising the brain, analogous to the way physical fitness is improved by exercising the body. Cognitive training activities can take place in numerous modalities such as cardiovascular fitness training, playing online games or completing cognitive tasks in alignment with a training regimen, playing video games that require visuospatial reasoning, and engaging in novel activities such as dance, art, and music.

Numerous studies have indicated that aspects of brain structure remain "plastic" throughout life. Brain plasticity reflects the ability for the brain to change and grow in response to the environment. There is ample debate within the scientific community on the efficacy of brain training programs and controversy on the ethics of promoting brain training software to potentially vulnerable subjects.