Nazarene is a title used to describe people from the city of Nazareth in the New Testament (there is no mention of either Nazareth or Nazarene in the Old Testament), and is a title applied to Jesus, who, according to the New Testament, grew up in Nazareth, a town in Galilee, located in ancient Judea. The word is used to translate two related terms that appear in the Greek New Testament: Nazarēnos ('Nazarene') and Nazōraios ('Nazorean'). The phrases traditionally rendered as "Jesus of Nazareth" can also be translated as "Jesus the Nazarene" or "Jesus the Nazorean", and the title Nazarene may have a religious significance instead of denoting a place of origin. Both Nazarene and Nazorean are irregular in Greek and the additional vowel in Nazorean complicates any derivation from Nazareth.
The Gospel of Matthew explains that the title Nazarene is derived from the prophecy "He will be called a Nazorean", but this has no obvious Old Testament source. Some scholars argue that it refers to a passage in the Book of Isaiah, with Nazarene a Greek reading of the Hebrew ne·tser ('branch'), understood as a messianic title. Others point to a passage in the Book of Judges which refers to Samson as a Nazirite, a word that is just one letter off from Nazarene in Greek. It is also possible that Nazorean signs Jesus as a ruler.