Naso Tjër Di Comarca in the context of Palo Seco Forest Reserve

Bocas del Toro (Spanish pronunciation: [ˈbokas ðel ˈtoɾo]; meaning "Mouths of the Bull") is a province of Panama. Its area is 4,643.9 square kilometers, comprising the mainland and nine main islands. The province consists of the Bocas del Toro Archipelago, Bahía Almirante (Almirante Bay), Chiriquí Lagoon, and adjacent mainland. The capital is the city of Bocas del Toro (or Bocas Town) on Isla Colón (Colón Island). Other major cities or towns include Almirante and Changuinola. The province has a population of 159,228 as of 2023.

Christopher Columbus and his crew first visited the area in 1502. Bocas del Toro borders the Caribbean Sea to the north, Limón Province of Costa Rica and the Naso Tjër Di Comarca to the west, Chiriquí Province to the south, and Ngöbe-Buglé Comarca to the east. The Río Sixaola forms part of the border with Costa Rica. A newly constructed bridge spans the river between Guabito and Sixaola, Costa Rica. The bridge is a border crossing used by tourists going between destinations in Bocas del Toro and Costa Rica.

Panama is divided into ten provinces (Spanish: provincias) and four provincial-level indigenous regions (Spanish: comarcas indígenas, often shortened to comarcas). The most recently established province is Panamá Oeste Province on 1 January 2014, and the most recently established indigenous region is Naso Tjër Di Comarca on 4 December 2020.

There are also two indigenous regions within provinces that are considered equivalent to a corregimiento (municipality).