Murine typhus, also known as endemic typhus or flea-borne typhus, is a form of typhus caused by Rickettsia typhi transmitted by fleas (Xenopsylla cheopis), usually on rats, in contrast to epidemic typhus which is usually transmitted by lice. Murine typhus is an under-recognized entity, as it is often confused with viral illnesses. Most people who are infected do not realize that they have been bitten by fleas. Historically the term "hunger-typhus" was used in accounts by British POWs in Germany at the end of World War I when they described conditions in Germany.
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Murine typhus in the context of Oriental rat flea
The Oriental rat flea (Xenopsylla cheopis), also known as the tropical rat flea or the rat flea, is a parasite of rodents, primarily of the genus Rattus, and is a primary vector for plague and murine typhus. This occurs when a flea that has fed on an infected rodent bites a human, although the flea can live on any warm blooded mammal.
Murine typhus in the context of Typhus
Typhus, also known as typhus fever, is a group of infectious diseases that include epidemic typhus, scrub typhus, and murine typhus. Common symptoms such as fever, headache, and a rash typically begin one to two weeks after exposure.
The diseases are caused by specific types of bacterial infection. Epidemic typhus is caused by Rickettsia prowazekii spread by body lice, scrub typhus is caused by Orientia tsutsugamushi spread by chiggers, and murine typhus is caused by Rickettsia typhi spread by fleas.
Murine typhus in the context of Rickettsia typhi
Rickettsia typhi is a small, aerobic, obligate intracellular, rod shaped gram negative bacterium. It belongs to the typhus group of the Rickettsia genus, along with R. prowazekii. R. typhi has an uncertain history, as it may have long gone shadowed by epidemic typhus (R. prowazekii). This bacterium is recognized as a biocontainment level 2/3 organism. R. typhi is a flea-borne disease that is best known to be the causative agent for the disease murine typhus, which is an endemic typhus in humans that is distributed worldwide. As with all rickettsial organisms, R. typhi is a zoonotic agent that causes the disease murine typhus, displaying non-specific mild symptoms of fevers, headaches, pains and rashes. There are two cycles of R. typhi transmission from animal reservoirs containing R. typhi to humans: a classic rat-flea-rat cycle that is most well studied and common, and a secondary periodomestic cycle that could involve cats, dogs, opossums, sheep, and their fleas.
R. typhi was once one of the most prevalent causes of rickettsial diseases worldwide, but has since experienced a drop in case reports with the implementation of pest control programs. The microorganism is concentrated in warmer climate and coastal ports where there is an abundance of rats and their fleas, which are the preferred hosts for the pathogen. R. typhi is transmitted between competent flea and mammalian hosts through flea bites and contact with infected feces and tissues.