Miguel Lopez de Legazpi in the context of Andrés de Urdaneta

The Battle of Mactan (Filipino: Labanan sa Mactan; Spanish: Batalla de Mactán) was fought on a beach in Mactan Island (now part of Cebu, Philippines) between Spanish forces led by the Portuguese explorer Ferdinand Magellan along with local allies, and Lapulapu, the chieftain of the island, on the early morning of April 27, 1521. Magellan, a Portuguese-born commander serving the Spanish Empire who led an expedition that ultimately circumnavigated the world for the first time, commanded a small Spanish contingent in an effort to subdue Mactan under the Spanish crown. The sheer number of Lapulapu's forces, compounded with issues associated with the location and the armor, ultimately resulted in a disastrous defeat for the Europeans and the death of Magellan. Surviving members of Magellan's crew continued the expedition under the command of Juan Sebastian de Elcano, who completed the journey in September 1522.

The battle's exact details are lost to history, with Antonio Pigafetta's account being the only source for much of the known information today. It is remembered in the Philippines as the first battle won by a native Filipino against Spanish forces, with Lapulapu being hailed as the country's first national hero. The Spanish Empire would continue to send expeditions to the archipelago with little to no success until Miguel Lopez de Legazpi's expedition to Cebu and Manila in 1565, starting a 333-year Spanish rule on the archipelago.