Michael Smith CC OBC FRS (April 26, 1932 – October 4, 2000) was a British-Canadian biochemist and businessman. He shared the 1993 Nobel Prize in Chemistry with Kary Mullis for his work in developing site-directed mutagenesis. Following a PhD in 1956 from the University of Manchester, he undertook postdoctoral research with Har Gobind Khorana (himself a Nobel Prize winner) at the British Columbia Research Council in Vancouver, British Columbia, Canada. Subsequently, Smith worked at the Fisheries Research Board of Canada Laboratory in Vancouver before being appointed a professor of biochemistry in the UBC Faculty of Medicine in 1966. Smith's career included roles as the founding director of the UBC Biotechnology Laboratory (1987 to 1995) and the founding scientific leader of the Protein Engineering Network of Centres of Excellence (PENCE). In 1996 he was named Peter Wall Distinguished Professor of Biotechnology. Subsequently, he became the founding director of the Genome Sequencing Centre (now called the Michael Smith Genome Sciences Centre) at the BC Cancer Research Centre.
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- ⭐ Core Definition: Michael Smith (chemist)
- Michael Smith (chemist) in the context of Polymerase chain reaction
- Michael Smith (chemist) in the context of Kary Mullis
Michael Smith (chemist) in the context of Polymerase chain reaction
The polymerase chain reaction (PCR) is a laboratory method widely used to amplify copies of specific DNA sequences rapidly, to enable detailed study. PCR was invented in 1983 by American biochemist Kary Mullis at Cetus Corporation. Mullis and biochemist Michael Smith, who had developed other essential ways of manipulating DNA, were jointly awarded the Nobel Prize in Chemistry in 1993.
PCR is fundamental to many of the procedures used in genetic testing, research, including analysis of ancient samples of DNA and identification of infectious agents. Using PCR, copies of very small amounts of DNA sequences are exponentially amplified in a series of cycles of temperature changes. PCR is now a common and often indispensable technique used in medical laboratory research for a broad variety of applications including biomedical research and forensic science.
View the full Wikipedia page for Polymerase chain reactionMichael Smith (chemist) in the context of Kary Mullis
Kary Banks Mullis (December 28, 1944 – August 7, 2019) was an American biochemist. In recognition of his role in the invention of the polymerase chain reaction (PCR) technique, he shared the 1993 Nobel Prize in Chemistry with Michael Smith and was awarded the Japan Prize in the same year. PCR became a central technique in biochemistry and molecular biology, described by The New York Times as "highly original and significant, virtually dividing biology into the two epochs of before PCR and after PCR."
Mullis downplayed humans' role in climate change, expressed doubt that HIV is the cause of AIDS, and professed a belief in astrology and the paranormal. He also practiced clandestine chemistry by producing LSD. Mullis's unscientific statements about topics outside his area of expertise have been named by Skeptical Inquirer as an instance of "Nobel disease".
View the full Wikipedia page for Kary Mullis