Medical research in the context of "Preclinical research"

Aelius Galenus or Claudius Galenus (Greek: Κλαύδιος Γαληνός; September 129 – c. 216 AD), often anglicized as Galen (/ˈɡeɪlən/) or Galen of Pergamon, was a Roman and Greek physician, surgeon, and philosopher. Considered to be one of the most accomplished of all medical researchers of antiquity, Galen influenced the development of various scientific disciplines, including anatomy, physiology, pathology, pharmacology, and neurology, as well as philosophy and logic.

The son of Aelius Nicon, a wealthy Greek architect with scholarly interests, Galen received a comprehensive education that prepared him for a successful career as a physician and philosopher. Born in the ancient city of Pergamon (present-day Bergama, Turkey), Galen traveled extensively, exposing himself to a wide variety of medical theories and discoveries before settling in Rome, where he served prominent members of Roman society and eventually was given the position of personal physician to several emperors.

The Dallas–Fort Worth metroplex, officially designated Dallas–Fort Worth–Arlington by the U.S. Office of Management and Budget, is the most populous metropolitan statistical area in the U.S. state of Texas and the Southern U.S., encompassing 11 counties. Its historically dominant core cities are Dallas and Fort Worth. It is the economic and cultural hub of North Texas. Residents of the area also refer to it as DFW (the code for Dallas Fort Worth International Airport) or the Metroplex. The Dallas–Fort Worth–Arlington metropolitan statistical area's population was 7,637,387 according to the U.S. Census Bureau's 2020 census, making it the fourth-largest metropolitan area in the U.S. and the eleventh-largest in the Americas. In 2016, the Dallas–Fort Worth metroplex had the highest annual population growth in the United States. By 2023, the U.S. Census Bureau estimated that the Dallas-Fort Worth metropolitan area's population had increased to 8,100,037, with the highest numerical growth of any metropolitan area in the United States. By 2025, NCTCOG estimated that the Dallas-Fort Worth metropolitan area's population had increased to around 8,578,654 million residents, making the Dallas-Fort Worth metropolitan area around 1.42 million residents from becoming a megacity.

The metropolitan region's economy, also referred to as Silicon Prairie, is primarily based on banking, commerce, insurance, telecommunications, technology, energy, healthcare, medical research, transportation, manufacturing, and logistics. As of 2022, Dallas–Fort Worth is home to 23 Fortune 500 companies, the 4th-largest concentration of Fortune 500 companies in the United States behind New York City (62), Chicago (35), and Houston (24). In 2016, the metropolitan economy surpassed Houston, the second largest metro area in Texas, to become the fourth-largest in the U.S. The Dallas–Fort Worth metroplex boasted a GDP of just over $620.6 billion in 2020 (although both metropolitan regions have switched places multiple times since GDP began recording). If the Metroplex were a sovereign state, it would have the twentieth largest economy in the world as of 2019. In 2015, the conurbated metropolitan area would rank the ninth-largest economy if it were a U.S. state. In 2020, Dallas–Fort Worth was recognized as the 36th best metropolitan area for STEM professionals in the U.S.

Pathology is the study of disease. The word pathology also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when used in the context of modern medical treatment, the term is often used in a narrower fashion to refer to processes and tests that fall within the contemporary medical field of "general pathology", an area that includes a number of distinct but inter-related medical specialties that diagnose disease, mostly through analysis of tissue and human cell samples. Pathology is a significant field in modern medical diagnosis and medical research. A physician practicing pathology is called a pathologist.

As a field of general inquiry and research, pathology addresses components of disease: cause, mechanisms of development (pathogenesis), structural alterations of cells (morphologic changes), and the consequences of changes (clinical manifestations). In common medical practice, general pathology is mostly concerned with analyzing known clinical abnormalities that are markers or precursors for both infectious and non-infectious disease, and is conducted by experts in one of two major specialties, anatomical pathology and clinical pathology. Further divisions in specialty exist on the basis of the involved sample types (comparing, for example, cytopathology, hematopathology, and histopathology), organs (as in renal pathology), and physiological systems (oral pathology), as well as on the basis of the focus of the examination (as with forensic pathology).

Research ethics is a discipline within the study of applied ethics. Its scope ranges from general scientific integrity and misconduct to the treatment of human and animal subjects. The social responsibilities of scientists and researchers are not traditionally included and are less well defined.

The discipline is most developed in medical research. Beyond the issues of falsification, fabrication, and plagiarism that arise in every scientific field, research design in human subject research and animal testing are the areas that raise ethical questions most often.

The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classified as a "Special Focus – Research Institution". Rockefeller is the oldest biomedical research institute in the United States.

The university is located on the Upper East Side of Manhattan, between 63rd and 68th streets on York Avenue. Richard P. Lifton became the university's eleventh president on September 1, 2016. The Rockefeller University Press publishes the Journal of Experimental Medicine, the Journal of Cell Biology, and The Journal of General Physiology.

The term citizen science (synonymous to terms like community science, crowd science, crowd-sourced science, civic science, participatory monitoring, or volunteer monitoring) is research conducted with participation from the general public, or amateur/nonprofessional researchers or participants of science, social science and many other disciplines. There are variations in the exact definition of citizen science, with different individuals and organizations having their own specific interpretations of what citizen science encompasses. Citizen science is used in a wide range of areas of study including ecology, biology and conservation, health and medical research, astronomy, media and communications and information science.

There are different applications and functions of "citizen science" in research projects. Citizen science can be used as a methodology where public volunteers help in collecting and classifying data, improving the scientific community's capacity. Citizen science can also involve more direct involvement from the public, with communities initiating projects researching environment and health hazards in their own communities. Participation in citizen science projects also educates the public about the scientific process and increases awareness about different topics. Some schools have students participate in citizen science projects for this purpose as a part of the teaching curriculums.

Clinical research is a branch of medical research that involves people and aims to determine the effectiveness (efficacy) and safety of medications, devices, diagnostic products, and treatment regimens intended for improving human health. These research procedures are designed for the prevention, treatment, diagnosis or understanding of disease symptoms.

Clinical research is different from clinical practice: in clinical practice, established treatments are used to improve the condition of a person, while in clinical research, evidence is collected under rigorous study conditions on groups of people to determine the efficacy and safety of a treatment.

A human–animal hybrid (or animal–human hybrid) is a hypothetical organism that incorporates elements from both humans and non-human animals. In a technical sense, a human–animal hybrid would be defined as an organism in which each cell contains both human and non-human genetic material. This contrasts with a non-human chimera in which some cells are human and the other are derived from a non-human organism (a human chimera, by contrast, consists entirely of human cells from different zygotes.)

Examples of human–animal hybrids mainly include humanized mice that have been genetically modified by xenotransplantation of human genes. Humanized mice are commonly used as small animal models in biological and medical research for developing human therapeutics.