Masolino da Panicale in the context of Virgin and Child with St. Anne (Masaccio)

The Brancacci Chapel (in Italian, "Cappella dei Brancacci") is a chapel in the Church of Santa Maria del Carmine in Florence, central Italy. It is sometimes called the "Sistine Chapel of the early Renaissance" for its painting cycle, among the most famous and influential of the period. Construction of the chapel was commissioned by Felice Brancacci and begun in 1422. The paintings were executed over the years 1425 to 1427. Public access is currently gained via the neighbouring convent, designed by Brunelleschi. The church and the chapel are treated as separate places to visit and as such have different opening times and it is quite difficult to see the rest of the church from the chapel.

The patron of the pictorial decoration was Felice Brancacci, descendant of Pietro, who had served as the Florentine ambassador to Cairo until 1423. Upon his return to Florence, he hired Masolino da Panicale to paint his chapel. Masolino's associate, 21-year-old Masaccio, 18 years younger than Masolino, assisted, but during painting Masolino left to Hungary, where he was painter to the king, and the commission was given to Masaccio. By the time Masolino returned he was learning from his talented former student. However, Masaccio was called to Rome before he could finish the chapel, and died in Rome at the age of 27. Portions of the chapel were completed later by Filippino Lippi. During the Baroque period some of the paintings were seen as unfashionable and a tomb was placed in front of them.

Santa Maria del Carmine is a church of the Carmelite Order, in the Oltrarno district of Florence, in Tuscany, Italy. It is famous as the location of the Brancacci Chapel housing outstanding Renaissance frescoes by Masaccio and Masolino da Panicale, later finished by Filippino Lippi.