Mary of Burgundy in the context of "Isabella of Bourbon"

Charles V (24 February 1500 – 21 September 1558) was Holy Roman Emperor and Archduke of Austria from 1519 to 1556, King of Spain (as Charles I) from 1516 to 1556, King of Sicily and Naples from 1516 to 1554, and also Lord of the Netherlands and titular Duke of Burgundy (as Charles II) from 1506 to 1555. He was heir to and then head of the rising House of Habsburg. His dominions in Europe included the Holy Roman Empire, extending from Germany to northern Italy with rule over the Austrian hereditary lands and Burgundian Low Countries, and Spain with its possessions of the southern Italian kingdoms of Sicily, Naples, and Sardinia. In the Americas, he oversaw the continuation of Spanish colonization and a short-lived German colonization. The personal union of the European and American territories he ruled was the first collection of realms labelled "the empire on which the sun never sets".

Charles was born in Flanders to Habsburg Archduke Philip the Handsome, son of Maximilian I, Holy Roman Emperor and Mary of Burgundy, and Joanna of Castile, younger child of Isabella I of Castile and Ferdinand II of Aragon, the Catholic Monarchs of Spain. Heir of his grandparents, Charles inherited his family dominions at a young age. After his father's death in 1506, he inherited the Habsburg Netherlands in the Low Countries. In 1516 he became King of Spain as co-monarch of Castile and Aragon with his mother. Spain's possessions included the Castilian colonies of the West Indies and the Spanish Main, as well as Naples, Sicily, and Sardinia. At the death of his grandfather Maximilian in 1519, he inherited the Austrian hereditary lands and was elected as Holy Roman Emperor. He adopted the Imperial name of Charles V as his main title, and styled himself as a new Charlemagne.

Habsburg Netherlands were the parts of the Low Countries that were ruled by sovereigns from the House of Habsburg. Their rule began in 1482 and ended for the Northern Netherlands in 1581 and for the Southern Netherlands in 1797. Habsburg rule began with the accession of Philip the Handsome in 1482, when he succeeded his mother Mary of Burgundy of the House of Valois-Burgundy, who was the ruler of the Low Countries. Philip's son and heir Charles, future King of Spain (1516), and the Holy Roman Emperor (1519), was born in the Habsburg Netherlands and made Brussels one of his capitals.

During the Habsburg era, from 1482 to 1797, parts of the Netherlands under their rule went through various political changes and administrative reorganizations. Becoming known as the Seventeen Provinces in 1549, they were held by the Spanish branch of the Habsburgs from 1556, thus becoming known as the Spanish Netherlands from that time on. In 1581, in the midst of the Dutch Revolt, the Seven United Provinces seceded from the rest of this territory to form the Dutch Republic. The remaining Spanish Southern Netherlands became the Austrian Netherlands in 1714, after Austrian acquisition under the Treaty of Rastatt. De facto Habsburg rule ended with the annexation by the revolutionary French First Republic in 1795. Austria, however, did not relinquish its claim over the country until 1797 in the Treaty of Campo Formio.

The Burgundian Netherlands were those parts of the Low Countries that were ruled by the House of Valois-Burgundy between 1384 and 1482. During the Burgundian Age, those lands were also parts of the wider Valois-Burgundian State, which itself belonged, in terms of suzerainty, partly to the Kingdom of France and partly to the Holy Roman Empire. The Valois Dukes of Burgundy gradually acquired and united those lowlands into a political union that went beyond a personal union establishing central institutions for the first time (such as the States General).

The period began with Duke Philip the Bold taking office as count and lord of Antwerp, Artois, Flanders, Mechelen, and Rethel in 1384, and lasted until the death of Duchess Mary of Burgundy in 1482, after which the Valois-Burgundian State was dissolved, as Mary's titles and lands were inherited by her son Philip the Handsome, from the House of Habsburg, thus initiating creation of the Habsburg Netherlands.

Philip the Handsome (22 June/July 1478 – 25 September 1506), also called Philip the Fair, was the first King of Castile from the House of Habsburg (as Philip I) for a brief time in 1506. He was also ruler of the Habsburg Netherlands from 1482, and additionally ruled over the counties of Artois, Burgundy and Charolais from 1493.

The son of archduke Maximilian of Austria (later Holy Roman Emperor as Maximilian I) and duchess Mary of Burgundy, Philip was not yet four years old when his mother died as a result of a riding accident, and upon her death in March 1482, he inherited her titles, and effective possessions in the Burgundian Netherlands, thus becoming the first Habsburg ruler of those lands, as confirmed by the Treaty of Arras in December 1482. Already in 1493, by the Treaty of Senlis, additional parts of his Burgundian inheritance were secured for Philip, including the counties of Artois, Burgundy and Charolais. Despite his young age, Philip quickly proved himself an effective ruler beloved by his people in the Low Countries, pursuing policies that favored peace and economic development, while maintaining a steady course of the government building.

The Spanish Netherlands (Spanish: Países Bajos Españoles; Dutch: Spaanse Nederlanden; French: Pays-Bas espagnols; German: Spanische Niederlande; historically in Spanish: Flandes, the name "Flanders" was used as a pars pro toto) were a collection of States of the Holy Roman Empire in the Low Countries, held in personal union by the Spanish Habsburgs, but not annexed to the Spanish Crown, thus encompassing the second period in history of the Habsburg Netherlands, that lasted from 1556 to 1714. This region comprised most of the modern states of Belgium and Luxembourg, as well as parts of northern France, the southern Netherlands, and western Germany, with the capital being Brussels. The Army of Flanders was given the task of defending the territory.

The Imperial fiefs in the former Burgundian Netherlands had been inherited by the House of Habsburg from the extinct House of Valois-Burgundy upon the death of Mary of Burgundy in 1482. The Seventeen Provinces formed the core of the Habsburg Netherlands, which passed to the Spanish Habsburgs upon the abdication of Emperor Charles V in 1556. Spanish hegemony in Netherlands was solidified following their victory in the Fall of Antwerp during the Eighty Years' War. When part of the Netherlands separated to form the autonomous Dutch Republic in 1581, the remainder of the area stayed under Spanish rule until the War of the Spanish Succession.

The Burgundian State (French: État bourguignon [eta buʁɡiɲɔ̃]; Dutch: Bourgondische Rijk [burˈɣɔndisə ˈrɛik]) was a composite monarchy ruled by the Dukes of Burgundy from the late 14th to the late 15th centuries, and which ultimately comprised not only the Duchy and County of Burgundy but also the Burgundian Netherlands. The latter, acquired piecemeal over time and largely through inheritance, was, in fact, their principal source of wealth and prestige. The Dukes were members of the House of Valois-Burgundy, a cadet branch of the French royal House of Valois, and the complex of territories they ruled is sometimes referred to as Valois Burgundy. The term "Burgundian State" was coined by historians and was not in contemporary use; the polity remained a collection of separate duchies and counties in personal union under the Duke of Burgundy.

It is regarded as one of the major powers in Europe of the 15th century. The Dukes of Burgundy were among the wealthiest and the most powerful princes in Europe and were sometimes called "Grand Dukes of the West". Including the thriving regions of Flanders and Brabant, the Burgundian State was a major centre of trade and commerce and a focal point of courtly culture that set the fashion for European royal houses and their courts. It nearly turned into a kingdom in its own right, but Charles the Bold's early death at the Battle of Nancy put an end to his Lotharingian dream and his legacy passed to the House of Habsburg through the marriage of his daughter Mary to Maximilian of Austria. Meanwhile Picardy and the Duchy of Burgundy were conquered by the King of France.