Marguerite Louise d'Orléans in the context of Anna Maria Luisa, Electress Palatine

Ferdinando de' Medici (9 August 1663 – 31 October 1713) was the eldest son of Cosimo III de' Medici, Grand Duke of Tuscany, and Marguerite Louise d'Orléans. Ferdinando was heir to the Grand Duchy of Tuscany, with the title Grand Prince, from his father's accession in 1670 until his death in 1713. He is remembered today primarily as a patron of music. An excellent musician himself (sometimes called "the Orpheus of princes"), he attracted top musicians to Florence and thus made it an important musical center. Through his patronage of Bartolomeo Cristofori, Ferdinando made possible the invention of the piano.

Anna Maria Luisa de' Medici (11 August 1667 – 18 February 1743) was an Italian noblewoman who was the last lineal descendant of the main branch of the House of Medici. A patron of the arts, she bequeathed the Medicis' large art collection, including the contents of the Uffizi, Palazzo Pitti, and the Medici villas, which she inherited upon her brother Gian Gastone's death in 1737, and her Palatine treasures to the Tuscan state, on the condition that no part of it could be removed from "the Capital of the grand ducal State....[and from] the succession of His Serene Grand Duke."

Anna Maria Luisa was the only daughter of Cosimo III de' Medici, Grand Duke of Tuscany, and Marguerite Louise d'Orléans, a niece of Louis XIII of France. On her marriage to Johann Wilhelm, Elector Palatine, she became Electress of the Palatinate, and, by patronising musicians, she earned for the contemporary Palatine court the reputation of an important music centre. As Johann Wilhelm had syphilis the union produced no offspring, which, combined with her siblings' barrenness, meant that the Medici were on the verge of extinction.

Gian Gastone de' Medici (born Giovanni Battista Gastone; 25 May 1671 – 9 July 1737) was the seventh and last Medicean grand duke of Tuscany.

He was the second son of Grand Duke Cosimo III and Marguerite Louise d'Orléans. His sister, Electress Palatine Anna Maria Luisa, arranged his marriage to the wealthy and widowed Anna Maria Franziska of Saxe-Lauenburg in 1697. The couple despised each other and had no children. As Grand Prince Ferdinando, Gian Gastone's elder brother, predeceased Cosimo III, Gian Gastone succeeded his father in 1723.

Cosimo III de' Medici (14 August 1642 – 31 October 1723) was Grand Duke of Tuscany from 1670 until his death in 1723, the sixth and penultimate from the House of Medici. He reigned from 1670 to 1723, and was the elder son of Grand Duke Ferdinando II. Cosimo's 53-year-long reign, the longest in Tuscan history, was marked by a series of laws that regulated prostitution and May celebrations. His reign also witnessed Tuscany's deterioration to previously unknown economic lows.

Cosimo III married Marguerite Louise d'Orléans, a cousin of Louis XIV. The marriage was solemnized by proxy in the King's Chapel at the Louvre, on 17 April 1661. It proved to be a very difficult marriage. Marguerite eventually abandoned Tuscany for the Convent of Montmartre. Together, they had three children: Ferdinando in 1663, Anna Maria Luisa, Electress Palatine, in 1667, and Gian Gastone I the last Medicean ruler of Tuscany, in 1671.