Mandrake in the context of Wellcome Museum of Anatomy and Pathology

The Twelve Tribes of Israel (Hebrew: שִׁבְטֵי־יִשְׂרָאֵל, romanized: Šīḇṭēy Yīsrāʾēl, lit. 'Staffs of Israel') are described in the Hebrew Bible as being the descendants of Jacob, a Hebrew patriarch who was a son of Isaac and thereby a grandson of Abraham. Jacob, later known as Israel, had a total of twelve sons, from whom each tribe's ancestry and namesake is derived: Reuben, Simeon, Levi, Judah, Dan, Naphtali, Gad, Asher, Issachar, Zebulun, Joseph, and Benjamin. Collectively known as the Israelites, they inhabited a part of Canaan—the Land of Israel—during the Iron Age. Their history, society, culture, and politics feature heavily in the Abrahamic religions, especially Judaism.

In the biblical narrative, after Moses oversaw the Israelites' departure from Egypt, he died and was succeeded by Joshua, who led the conquest of Canaan and subsequently allotted territory for all but the Tribe of Levi, which was instead dedicated 48 cities. This development culminated in the establishment of Israel and Judah, purportedly beginning with a Kingdom of Israel and Judah before splitting into the Kingdom of Israel in the north and the Kingdom of Judah in the south.

Leah (/ˈliːə/) appears in the Hebrew Bible as one of the two wives of the Biblical patriarch Jacob. Leah was Jacob's first wife, and the older sister of his second (and favored) wife Rachel. She is the mother of Jacob's first son Reuben. She has three more sons, namely Simeon, Levi and Judah, but does not bear another son until Rachel offers her a night with Jacob in exchange for some mandrake root (דודאים, dûdâ'îm). Leah gives birth to two more sons after this, Issachar and Zebulun, and to Jacob's only daughter, Dinah.

Mandragora is a plant genus belonging to the nightshade family (Solanaceae). Members of the genus are known as mandrakes. Between three and five species are placed in the genus. The one or two species found around the Mediterranean constitute the mandrake of ancient writers such as Dioscorides. Two or three further species are found eastwards into China. All are perennial herbaceous plants, with large tap roots and leaves in the form of a rosette. Individual flowers are bell-shaped, whitish through to violet, and followed by yellow or orange berries.

Like many members of the Solanaceae, species of Mandragora contain highly biologically active alkaloids that make the plants poisonous. Their roots in particular have a long use in traditional medicine. Mandrakes are involved in many myths and superstitions.